A. Refereed Papers

  1. Chen, C.-H. (1984). A correlation goodness-of-fit test for randomly censored data. Biometrika, 71, 315-322. DOI: 10.1093/biomet/71.2.315.
  2. Evans, W.E., Stewart, C.F., Chen, C.-H., Crom, W.R., Bowman, W.P., Abromowitch, M. and Simone, J.V. (1984). Methotrexate systemic clearance influences probability of relapse in children with standard-risk acute lymphocytic leukaemia. Lancet, 8373, 359-362. DOI: 10.1016/s0140-6736(84)90411-2.
  3. Chen, C.-H. and George, S.L. (1985). The bootstrap and identification of prognostic factors via Cox's proportional hazards regression model. Statistics in Medicine, 4, 39-46. DOI: 10.1002/sim.4780040107.
  4. Zee, P., DeLeon, M., Roberson, P. and Chen, C.-H. (1985). Nutritional improvement of poor urban preschool children: A 1983-1977 comparison. Journal of the American Medical Association, 253, 3269-3272. DOI:10.1001/jama.1985.03350460069023.
  5. Zee, P. and Chen, C.-H. (1986). Prevalence of obesity in children after therapy for acute lymphoblastic leukemia. American Journal of Pediatric Hematology Oncology, 8, 294-299. DOI: 10.1097/00043426-198624000-00005.
  6. Taiwan Children's Cancer Study Group. (1989). Treatment of childhood acute lymphoblastic leukemia with protocol TCL821: A report of Taiwan Children's Cancer Study Group. Journal of the Formosan Medical Association, 88, 48-56.
  7. Chen, H.-Y., Hsieh, F.-J., Tseng, L.-H., Lee, C.-N., Chang, F.-M., Chen, J.-S.(C.-H.), Cheng, S.-J. and Kao, M.-L. (1991). Doppler waveforms study in normal Chinese fetus. Journal of Ultrasound in Medicine of the R.O.C., 8, 122-137.
  8. Chen, C.-H. and Wang, P.C. (1991). Diagnostic plots in Cox's regression model. Biometrics, 47, 841-850. DOI: 10.2307/2532643.
  9. Kuk, A.Y.C. and Chen, C.-H. (1992). A mixture model combining logistic regression with proportional hazards regression. Biometrika, 79, 531-541. DOI: 10.2307/2336784.
  10. Lin, F.-S., Heish, T.-S., Chiu, T.Y., Chen, J., Tsai, T.-C., Hsu, T.-C., Chiang, W.-H., How, S.-W. and Chen, C.-H. (1992). Clinic pathological study of the bladder tumor: Prognostic factors of 188 cases. Journal of the Urological Association of R.O.C., 3, 921-926. (In Chinese, with English abstract.)
  11. Hu, H.-H., Chung, C., Liu, T.J., Chen, R.C., Chen, C.-H., Chou, P., Huang, W.-S., Lin, J.C.T. and Tsuei, J.J. (1993). A randomized controlled trial on the treatment for acute partial ischemic stroke with acupuncture. Neuroepidemiology, 12, 106-113. DOI: 10.1159/000110308.
  12. Chen, C.-H., Chou, P., Hu, H.-H. and Tsuei, J.J. (1994). Further analysis of a pilot study for planning an extensive clinical trial in traditional medicine - with an example of acupuncture treatment for stroke. American Journal of Chinese Medicine, XXII, 127-136. DOI: 10.1142/s0192415x94000164.
  13. Chang, I.S., Chen, C.-H. and Hsiung, C.A. (1994). Estimation in change-point hazard rate models with random censorship. In: Change-point Problems (E. Carlstein, H. G. Muller and D. Siegmund, eds.), Lecture Notes - Monograph Series Volume 23, 78-92. Institute of Mathematical Statistics, Hayward, California.
  14. Chi, K.-H., Chen, C.-H., Chan, W.-K., Chow, K.-C., Chen, S.-Y., Yen, S.-H., Chao, J-Y., Chang, C.-Y. and Chen, K.-Y. (1995). Effect of granulocyte-macrophage colony- stimulating factor on oral mucositis in head and neck cancer patients after cisplatin, fluorouracil, and leucovorin chemotherapy. Journal of Clinical Oncology, 13, 2620-2628. DOI: 10.1200/JCO.1995.13.10.2620.
  15. Hwu, H.-G., Chen, C.-H., Rin, H., Chen, C.-J., Chang, S.-H., Huang, M.-G. and Yeh, J. J. (1996). The distribution of psychiatric beds in Taiwan. Chinese Psychiatry, 10, 45-53. (In Chinese, with English abstract.)
  16. Hwu, H.-G., Chen, C.-H., Rin, H., Chen, C.-J., Chang, S.-H., Huang, M.-G. and Yeh, J. J. (1996). Hospital locality and domicile of psychiatric inpatients. Chinese Psychiatry, 10, 166-174. (In Chinese, with English abstract.)
  17. Chen, C.-H., Tsai, W.-Y. and Chao, W.-H. (1996). The product-moment correlation coefficient and linear regression for truncated data. Journal of the American Statistical Association, 91, 1181-1186. DOI: 10.2307/2291736.
  18. Wu, A. C.-C., Huang, M.-K., Hwu, H.-G. and Chen, C.-H. (1999). Change of expressed emotion in the family members of schizophrenic patients over a two-year period. Taiwanese Journal of Psychiatry, 13, 54-64. (In Chinese, with English abstract.)
  19. Hwu, H,-G., Wu, A.C.C., Cheng, J.J., Huang, M,-G., Hu, S.-P., Chen, C.-H., Yeh, L.-L. and Chang, H.-J. (2000). The burden on chief caregivers of patients with schizophrenia. Taiwanese Journal of Psychiatry, 14, 205-217.
  20. Lin, C.-Y., Sheng, C.-C., Chen, C.-H., Lin, C.-C. and Chou, P. (2000). The prevalence of heavy proteinuria and progression risk factors in children undergoing urinary screening. Pediatric Nephrology, 14, 953-959. DOI: 10.1007/s004679900278.
  21. Wu, H.-D. I., Hsieh, F. and Chen, C.-H. (2002). Validation of a heteroscedastic hazard regression model. Lifetime Data Analysis, 8, 21-34. DOI: 10.1023/a:1013566631377.
  22. Hwu, H. G., Chen, C. H., Hwang, T. J., Liu, C. M., Cheng, J. J., Lin, S. K., Liu, S. K., Chen, C. -H., Chi, Y. Y., OuYoung, C. W., Lin, H. N. and Chen, W. J. (2002). Symptom patterns and subgrouping of schizophrenic patients: significance of negative symptoms assessed on admission. Schizophrenia Research, 56, 105-119. DOI: 10.1016/S0920-9964(01)00251-1.
  23. Wu, J.-F., Chen, C.-H., Hsieh, R.-P., Shih, H.-H., Chen, Y.-H., Li, C.-R., Chiang, C.-Y., Shau, W.-Y., Ni, Y.-H., Chen, H.-L., Hsu, H.-Y. and Chang, M.-H. (2006). HLA typing associated with hepatitis B e-antigen seroconversion in children with chronic hepatitis B virus infection: A long-term prospective sibling cohort study in Taiwan. Journal of Pediatrics, 148, 647-651. DOI: 10.1016/j.jpeds.2005.12.025.
  24. Su, L-J., Chang, C.-W., Wu, Y.-C., Chen, K.-C., Lin, C.-J., Liang, S.-C., Lin, C.-H., Whang-Peng, J., Hsu, S.-L., Chen, C.-H.* and Huang, C.-Y. F.* (2007). Selection of DDX5 as a novel internal control for Q-RT-PCR from the microarray data via the block bootstrap re-sampling scheme. BMC Genomics, 8: 140. DOI: 10.1186/1471-2164-8-140. (* Correspondence authors)
  25. Yeh, L.-L., Hwu, H.-G., Chen, C.-H., Chen, C.-H. and Wu, A. C. C. (2008). Factors related to perceived needs of primary caregivers of patients with schizophrenia. Journal of Formosan Medical Association, 107, 644-652. DOI: 10.1016/S0929-6646(08)60182-5.
  26. Huang, G.-H., Hsieh, C.-C., Chen, C.-H. and Chen, W. J. (2009). Statistical validation of endophenotypes using a surrogate endpoint analytic analogue. Genetic Epidemiology, 33, 549-558. DOI: 10.1002/gepi.20407.
  27. Lue, H.-H., Chen, C.-H. and Chang, W.-H. (2011). Dimension reduction in survival regressions with censored data via an imputed spline approach. Biometrical Journal, 53, 426-433. DOI: 10.1002/bimj.201000168.
  28. Huang, G.-H., Tsai, H.-H., Hwu, H.-G.*, Chen, C.-H., Liu, C.-C. Hua, M.-S. and Chen, W. J. (2011). Patient subgroups of schizophrenia based on the Positive and Negative Syndrome Scale: composition and transition between acute and subsided disease states. Comprehensive Psychiatry, 52, 469-478. DOI: 10.1016/j.comppsych. 2010.10.012.
  29. Wu, J.-F., Su, Y.-R., Chen, C.-H., Ni, Y.-H., Chen, H.-L., Hsu, H.-Y., Wang, J.-L.* and Chang, M.-H.* (2012). Predictive effect of serial serum alanine aminotransferase levels on spontaneous HBeAg seroconversion in chronic genotypes B and C HBV infected children. Journal of Pediatric Gastroenterology and Nutrition, 54, 97-100. DOI: 10.1097/MPG.0b013e31822a033e.
  30. Chiang, J.-T., Lin, C.-Y., Fu, T.-T. and Chen, C.-H. (2012). Using stated-preference and prior purchase intention in the estimation of willingness to pay a premium for genetically modified foods. Agribusiness, 28, 103-117. DOI: 10.1002/agr.20291.
  31. Liu, C.-C., Chen, C.-H., Hwu, H.-G., Shiu, S.-Y., Hua, M.-S., Chen, C.-H., Hwang, T.-J., Liu, C.-M., Hsieh, M.-H., Liu, S.-K. and Chen, W. J. (2012) Medium-term course and outcome of schizophrenia depicted by the sixth-month subtype after an acute episode. Journal of Formosan Medical Association, 111, 265–274. DOI: 10.1016/j.jfma.2011.01.007.
  32. Pan, Y.-J., Chang, W-H., Lee, M.-B.*, Chen, C.-H., Liao, S.-C. and Caine, E. D. (2013). Effectiveness of a nationwide aftercare program for suicide attempters. Psychological Medicine, 43, 1447-1454. DOI: 10.1017/S0033291712002425.
  33. Chen, C.-H., Tsay, Y.-C., Wu, Y.-C. and Horng, C.-F. (2013). Logistic-AFT location-scale mixture regression models with nonsusceptibility for left-truncated and general interval-censored data. Statistics in Medicine, 32, 4285-4305. DOI: 10.1002/sim.5845.
  34. Chen, C.-M. and Chen, C.-H. (2016). Heteroscedastic transformation cure regression models. Statistics in Medicine, 35, 2359-2376. DOI: 10.1002/sim.6896.
  35. Tsay, Y.-C., Chen, C.-H.* and Pan, W.-H. (2016). Ages at onset of 5 cardiometabolic diseases adjusting for nonsusceptibility: Implications for the pathogenesis of metabolic syndrome. American Journal of Epidemiology, 184, 366-377. DOI: 10.1093/aje/kwv449.
  36. Yang, H.-C., Chen, I-C., Tsay, Y.-C., Li, Z.-R., Chen, C.-h., Hwu, H.-G. and Chen, C.-H.* (2017). Using an event-history with risk-free model to study genetics of alcoholism. Scientific Reports, 7: 1975. DOI:10.1038/s41598-017-01791-4.
  37. Yang, P.-K., Hsu, C.-Y., Chen, M.-J.*, Lai, M.-Y., Li, Z.-R., Chen, C.-H., Chen, S.-U., Ho, H.-N. (2018). The efficacy of 24-month metformin for improving menses, hormone and metabolic profiles in polycystic ovary syndrome. Journal of Clinical Endocrinology and Metabolism, 103, 890-899. DOI: 10.1210/jc.2017-01739.
  38. Hsu, C.-Y., Chen, C.-H.*, Hsu, K.-N. and Lu, Y.-H. (2019). A useful design utilizing the information fraction in a group sequential clinical trial with censored survival data. Biometrics, 75, 133-143. DOI: 10.1111/biom.12925.
  39. Chiang, K.-M., Tsay, Y.-C., Ng, T.-C. V., Yang, H.-C., Huang, Y.-T., Chen, C.-H. * and Pan, W.-H. * (2019). Is hyperuricemia, an early-onset metabolic disorder, causally associated with cardiovascular disease event in Han Chinese? Journal of Clinical Medicine, 8, 1202. DOI:10.3390/jcm8081202.
  40. Chang, H.-J., Yang, U.-C.*, Lai, M.-Y., Chen, C.-H. and Fann, Y.-C. (2022). High BRCA1 gene expression increases the risk of early distant metastasis in ER+ breast cancers. Scientific Reports, 12: 77. DOI:10.1038/s41598-021-03471-w.
  41. Kuo, H.-H., Chen, C.-H., Chiang, J.-T.*, Lee, M.-B.* and Liao, S.-C. (2022). Identification of suicide ideation and associated risk factors for the elderly receiving home care services. Journal of Suicidology, 17, 59-66. DOI: 10.30126/JoS.202203_(1).0003.

B. Statistical Software

  1. Tsay, Y.-C., Chen, C.-H., Wu, Y.-C. and Horng, C.-F. (2017). MixtureRegLTIC: Mixture regression models for left-truncated and interval-censored data. R package, version 1.0.0,, Comprehensive R Archive Network.
  2. Hsu, C.-Y. and Chen, C.-H. (2018). SurvGSD: Group sequential design for a clinical trial with censored survival data. R package, Version 1.0.0,, Comprehensive R Archive Network.