Shieh Lab

    

Welcome to Shieh Lab.

News

"Whole-genome sequencing reveals rare variants associated with gout in Taiwanese males" has been accepted for publication in Frontiers in Genetics (section Genetics of Common and Rare Diseases) in 2024

"Feature selection translates drug response predictors from cell lines to patients" has been published in Frontiers in Genetics in 2023

 

Teaching


Data Science Program, Academic Sinica & NTU

Bioinformatics at Taiwan International Graduate Program

Translational Medicine at TIGP

Research Topics/Projects

  1. Machine Learning-based projects on precision medicine.
    To find signatures for prediction of response of patients with Urothelial/Kidney cancer to immunotherapies.
    (
    a collaboration with Dr.
     Tai-Lung Cha, Director of National Institute of Cancer Research, NHRI)
    Cha.jpg
  2. Identifying Rare Variants of gout in Taiwanese males via whole-genome sequencing.
    (collaborate with Prof. Jan-Gowth Chang (China Medical Univ./Changhua Show Chwan Memorial Hospital))

    Chang.jpg
  3. Using deep learning (cNN) to identify cancer patients who can response to drugs.
    (collaborate with Prof. Jan-Gowth Chang (China Medical Univ./Changhua Show Chwan Memorial Hospital))
  4. Identifying (a) prognostic markers, (b) drug target and (c) key genes in colorectal/Lung/ Oral cancers. (collaborated with profs. Pai-Chye Yang (National Taiwan Univ.); Joanne Chen (IBMS); Jan-Gowth Chang (CMU), and others)
    Related publications:
    Tiong et al. (2014), Hwang et al. (2015),
    Chang et al. (2016), Wang et al. (2019).
  5. Using several kinds of genomic data to infer genetic interactions/pathway components.

 

 

Institute of Statistical Science, Academia Sinica, 128, Academia Rd. Sec. 2, Taipei 115, Taiwan