楊欣洲博士個人網站

楊欣洲

Hsin-Chou Yang

Institute of Statistical Science, Academia Sinica
Taipei 11529, Taiwan, R.O.C.
Tel: +886-27875686
FAX: +886-2-27886833
E-mail: hsinchou@stat.sinica.edu.tw

Narrative CV

Dr. Hsin-Chou Yang is a statistician, bioinformatician, and data scientist specializing in big data analytics for biomedical and life sciences. Currently, he is a Full Research Fellow and Director at the Institute of Statistical Science, Academia Sinica. Dr. Yang’s work bridges methodological innovation and practical biomedical applications. His contributions span multi-omics integration and precision & smart health. His team’s findings on COVID-19 viral subtypes, published in PNAS and PNAS Nexus, on AI-driven diabetes risk models, published in Nature Communications, and on a large Han Chinese ancestry cohort for precision medicine, published in Nature, exemplify impactful research. Dr. Yang has received numerous honors, including the Presidential Scholar of Academia Sinica, the Future Technology Breakthrough Award, and the National Innovation Award. He is an elected member of the International Statistical Institute and the Global Young Academy. He has served as an Associate Editor for major journals, provided paper review for more than 70 journals, and has chaired several national and international conferences. He actively mentors young scientists and contributes to scientific policy and review boards. 

Research Interests (PDF1, PDF2, PDF3)

Data sciences for the multi-omics and precision & smart health studies (Project website)

Education

1990 - 1994

B.S., Department of Statistics, National Cheng Kung University

1994 - 1996

M.S., Graduate Institute of Statistics, National Cheng Kung University

1996 - 2002

Ph.D., Institute of Statistics, National Tsing Hua University

Professional Experience 

2002.10 - 2004.06

Postdoctoral Fellow of National Science Council @ Institute of Biomedical Sciences, Academia Sinica [In military service]

2004.07 - 2006.06

Postdoctoral Fellow of Academia Sinica @ Institute of Biomedical Sciences, Academia Sinica [In military service]

2006.07 - 2011.03

Assistant Research Fellow @ Institute of Statistical Science, Academia Sinica

2011.03 - 2018.01

Associate Research Fellow @ Institute of Statistical Science, Academia Sinica

2018.01 - Present

Research Fellow @ Institute of Statistical Science, Academia Sinica

Publications (^CA Correspondence author; ^EC Equal contribution; ^JS Joint supervision) (Google Scholar)

- Journal Papers

1.

Dunneram, Y.^EC, Lee, J. Y.^EC, Watling C. Z.^EC, Lawson I., Parsaeian M., Fraser G. E., Butler F. M., Prabhakaran D., Shridhar K., Kondal D., Mohan V., Ali M. K., Venkat Narayan K. M., Tandon N., Tong T. Y. N., Travis R. C., Chiu T. H. T., Lin M.-N., Lin C.-L., Yang, H.-C. (20th), Liang, Y.-J., Greenwood, D. C., Reeves, G. K., Papier K., Floud S., Sinha R., Liao, L. M., Loftfield, E., Cade, J. E., Key T. J.^CA, and Perez-Cornago, A. (2026/02). Vegetarian diets and cancer risk: pooled analysis of 1.8 million women and men in nine prospective studies on three continents. British Journal of Cancer 134, 1218-1229. [SCI]

2.

Liang, Y.-J., Yang, C.-T., Chen, C.-W., Lin, Y.-C., Lin, S.-Y., Wang, Y.-S.^CA and Yang, H.-C.^CA (2025/11). SMART 2.0 Statistical Metabolomics Analysis: An R tool 2.0. Analytical Chemistry 97 (46), 25453–25468. [SCI] (https://doi.org/10.1021/acs.analchem.5c03225)

3.

Yang, H.-C.^{CA, EC}, Kwok, P.-Y.^{CA, EC}, Li, L.-H.^EC, Liu, Y.-M.^EC, Jong, Y.-J.^EC, Lee, K.-Y.^EC, Wang, D.-W., Tsai, M.-F., Yang, J.-H., Chen, C.-H., Yeh, E.-C., Wei, C.-Y., Fann, C. S. J., Huang, Y.-T., Chen, C.-W., Lee, Y.-J., Chu, S.-K., Ho, C.-H., Yang, C.-S., Lee, Y. L., Chen, H.-H., Hou, M.-C., Chiou, J.-F., Yang, S.-F., Wang, C.-H., Huang, C.-Y., Chiu, K.-M., Chen, M., Chiang, F.-T., Lee, S.-L., Chen, S.-S., Yao, W.-J., Chien, C.-C., Lin, S.-Y., Chang, F.-P., Ho, H.-L., Yeh, Y.-C., Tseng, W.-C., Lin, M.-H., Chang, H.-T., Tseng, L.-M., Liang, W.-Y., Chen, P. C.-H., Hang, J.-F., Lin, S.-C., Chan, Y.-J., Kuo, Y.-J., Wang, L.-C., Pan, C.-C., Hsieh, Y.-C., Chen, Y.-M., Hsiao, T.-H., Lin, C.-H., Chen, Y.-J., Chen, I.-C., Mao, C.-L., Chang, S.-J., Chang, Y.-L., Liao, Y.-J., Lai, C.-H., Lee, W.-J., Tung, H., Yen, T.-T., Yen, H.-C., Shih, C.-M., Chou, T.-Y., Liou, T.-H., Chiang, C.-Y., Cherng, Y.-G., Chen, C.-H., Chiu, C.-H., Tseng, S.-H., Lin, E. P.-Y., Chen, Y.-J., Chuang, H.-P., Chen, T.-C., Huang, W.-T., Sin, J., Liu, I.-L., Chen, Y.-C., Chao, K.-K., Wu, Y.-M., Yu, P.-P., Chang, L.-P., Yen, K.-Y., Chang, L.-C., Sheen, Y.-J., Chen, Y.-T., Kan, K., Tsai, H.-L., Wang, Y.-K., Hou, M.-F., Yang, Y.-H., Kuo, C.-H., Wu, W.-J., Huang, J.-F., Chong, I.-W., Tsai, J.-R., Lin, C.-Y., Yu, M.-C., Lee, T.-H., Tsai, M.-H., Ou, Y.-C., Chen, P.-Y., Hu, T.-H., Shyu, Y.-C., Cheng, C.-K., Fang, Y.-J., Hsieh, S.-C., Chen, C.-H., Chen, C.-C., Li, K.-J., Lin, C.-H., Chiu, H.-Y., Wu, C.-C., Chen, C.-Y., Chu, S.-J., Liu, F.-C., Yang, F.-C., Chang, H.-A., Chen, W.-L., Yang, S.-S., Sung, Y.-F., Wang, T.-F., Lin, S.-Z., Wu, Y.-W., Wu, C.-S., Jiang, J.-Y., Ma, G.-C., Chang, T.-Y., Hwang, J.-J., Kao, K.-J., Hung, C.-F., Chiu, T.-F., Chen, P.-Y., Tsui, K., Wu, M.-S.^JS, Pang, S.-T.^JS, Chen, S.-A.^JS, Chen, W.-M.^JS, Chen, C.-h.^JS, Sheu, Wayne H.-H.^JS, Wu, J.-Y.^CA,JS (2025/10). The Taiwan Precision Medicine Initiative provides a cohort for large-scale studies. Nature 648, 117-127. [SCI] (https://rdcu.be/eLNnv)

4.

Chen, H.-H.^{CA, EC}, Chen, C.-H.^EC, Hou, M.-C.^EC, Fu, Y.-C.^EC, Li, L.-H., Chou, C.-Y., Yeh, E.-C., Tsai, M.-F., Chen, C.-h., Yang, H.-C. (10th), Huang, Y.-T., Liu, Y.-M., Wei, C.-y., Su, J.-P., Lin, W.-J., Wang, E.H.F., Chiang, C.-L., Jiang, J.-K., Lee, I.-H., Liang, K.-H., Chen, W.-S., Tsai, H.-C., Lin, S.-Y., Chang, F.-P., Ho, H.-L., Yeh, Y.-C., Tseng, W.-C., Lin, M.-H., Chang, H.-T., Tseng, L.-M., Liang, W.-Y., Chen, P.C.-H., Hsieh, Y.-C., Chen, Y.-M., Hsiao, T.-H., Lin, C.-H., Chen, Y.-J., Chen, I.-C., Mao, C.-L., Chang, S.-J., Chang, Y.-L., Liao, Y.-J., Lai, C.-H., Lee, W.-J., Tung, H., Yen, T.-T., Yen, H.-C., Chen, M.-Y., Lin, Y.-C., Kao, Y.-T., Kao, B.-Z., Lee, J.-E., Chung, C.-L., Liu, J.-C., Chan, P., Lin, C.-H., Chen, C.-H., Wu, I.-C., Lin, L.-C., Wang, J.-W., Shih, S.-L., Hsieh, S.-W., Hung, C.-H., Li, W.-M., Yang, C.-J., Yang, C.-S., Weng, R.-H., Chen, Y.-C., Chang, C.-P., Wu, T.-H., Lin, Y.-C., Sheen, Y.-J., Wang, S.-H., Chen, S.-P., Raben, T., Widen, E., Hsu, S., Hsieh, F.-J., Ho, D.-R., Huang, Y.-H., Yang, C.-H., Huang, Y.-S., Chen, Y.-F., Wu, H.-M., Tsai, P.-H., Huang, K.-G., Chien, C.-Y., Ho, Y.-L., Wu, M.-S., Kao, J.-H., Liu, Y.-B., Juang, J.-M.J., Lin, M.-H., Lin, Y.-H., Lee, J.-Y., Lu, H.-J., Lu, C.-H., Feng, A.-C., Liu, J.-S., Chiang, C.-P., Chu, N.-F., Lin, J.-C., Yeh, Y.-W., Meng, E., Huang, C.-Y., Li, C.-C., Wang, T.-F., Su, K.-Y., Wang, J.-K., Chen, M.-H., Chen, H.-F., Ma, G.-C., Chang, T.-Y., Chiang, F.-T., Chang, H.-J., Kao, K.-J., Hung, C.-F., Tsai, C.-Y., Chen, P.-Y., Tsui, K., Chen, Y.-T., Kwok, P.-Y., Sheu, W.H.-H.^JS, Yang, S.-F.^JS, Liou, J.-M.^JS, Wang, J.-Y.^JS, Chiou, J.-F.^JS, Wu, J.-Y.^JS, Fann, C. S. J.^CA,JS (2025/10). Population-Specific Polygenic Risk Scores Developed for the Han Chinese. Nature 648, 128-137. [SCI] (https://rdcu.be/eLMR9)

5.

Wei, C.-Y.^CA, Wen, M.-S., Cheng, C.-K., Sheen, Y.-J., Yao, T.-C., Lee, S.-L., Wu, J.-Y., Tsai, M.-F., Li, L.-H., Chen, C.-h., Fann, C.S.J., Yang, H.-C. (12th), Huang, Y.-T., Chen, H.-H., Liu, Y.-M., Yeh, E.-C., Peng, Y.-C., Wang, S.-J., Chen, S.-P., Tsai, M.-T., Huo, T.-I., Su, C.-W., Tarng, D.-C., Huang, C.-C., Fuh, J.-L., Lan, K.-H., Liu, Y.-T., Lu, C.-L., Lee, Y.-C., Huang, Y.-H., Li, C.-P., Wang, Y.-F., Hsieh, Y.-C., Chen, Y.-M., Hsiao, T.-H., Lin, C.-H., Chen, Y.-J., Chen, I.-C., Mao, C.-L., Chang, S.-J., Chang, Y.-L., Liao, Y.-J., Lai, C.-H., Lee, W.-J., Tung, H., Yen, T.-T., Yen, H.-C., Chang, J.-H., Huang, C.-Y., Chan, L., Lin, Y.-W., Hsiao, B.-Y., Hu, C.-J., Lin, Y.-K., Lin, Y.-F., Chang, T.-C., Wu, D.-C., Kan, J.-Y., Hsu, C.-Y., Chen, S.-C., Li, C.-C., Huang, C.-F., Sheu, C.-C., Yang, L.-J., Chen, C.-H., Chen, K.-M., Chang, S.-M., Liou, M.-S., Wang, S.-P., Lin, K.-T., Chuang, H.-P., Chen, Y.-J., Sin, J., Chen, Y.-T., Chang, C.-C., Kuo, C.-F., Lin, J.-C., Kuo, H.-C., Chan, T.-M., Lee, C.-W., Lai, J.-H., Luo, S.-F., Cheng, H.-T., Lin, L.-Y., Chang, L.-C., Tsai, C.-T., Kao, H.-L., Yu, J.-J., Jeng, J.-S., Chiu, M.-C., Hong, T.-C., Yang, S.-F., Lu, H.-J., Su, S.-C., Chu, P., Li, P.-F., Tsai, C.-L., Tsai, C.-K., Tang, S.-E., Lin, C.-M., Wu, Y.-F., Huang, C.-Y., Ling, S.-Z., Chang, C.-C., Lin, T.-K., Hsiao, S.-M., Chang, C.-H., Chen, C.-D., Ma, G.-C., Chang, T.-Y., Hwang, J.-J., Lu, C.-L., Kao, K.-J., Hung, C.-F., Chen, S.-S., Chen, P.-Y., Tsui, K., Chen, Y.-T., Chen, C.-H., Chien, C.-C., Chiang, H.-S., Chiu, Y.-L., Chen, H.-C., Kwok, P.-Y. ^CA (2025/06). Clinical impact of pharmacogenetic risk variants in a large Chinese cohort. Nature Communications 16, 6344. [SCI]

6.

Dunneram, Y.^CA, Lee, J.Y., Watling, C.Z., Fraser, G.E., Miles, F., Prabhakaran, D., Shridhar, K., Kondal, D., Mohan, V., Ali, M.K., Narayan, K.M.V., Tandon, N., Tong, T.Y.N., Chiu, T.H.T., Lin, M.-N., Lin, C.-L., Yang, H.-C. (17th), Liang, Y.-J., Greenwood, D.C., Du, H., Chen, Z., Yu, C., Kakkoura, M.G., Reeves, G.K., Papier, K., Floud, S., Sinha, R., Liao, L.M., Loftfield, E., Cade, J.E., Key, T.J.^CA, Perez-Cornago, A. (2024/08). Methods and participant characteristics in the Cancer Risk in Vegetarians Consortium: a cross-sectional analysis across 11 prospective studies. BMC Public Health 24, 2095. [SCI]

7.

Huang, Y.-J., Chen, C.-h. and Yang, H.-C.^CA (2024/05). AI-enhanced integration of genetic and medical imaging data for risk assessment of type 2 diabetes. Nature Communications 15, 4230. [SCI] (https://rdcu.be/dIiU4)

8.

Yen, T.-J.^CA, Yang, C.-T., Lee, Y.-J., Chen, C.-h. and Yang, H.-C. (2024/03). Fatty liver classification via risk controlled neural networks trained on grouped ultrasound image data. Scientific Reports 14, 7345. [SCI]

9.

Wang, Y.-W., Yang, H.-C., Chen, Y.-H. and Guo, C.-Y.^CA (2024/01). Generalized estimating equations boosting (GEEB) machine for correlated data. Journal of Big Data 11, 20. [SCI]

10.

Tsai, P.-H., Sun, J.-R., Chien Y., Chan, M. S., Khor, W., Yang, H.-C., Huang, C.-H., Hsiung, C.-N., Hwa, T.-Y., Lin, Y.-Y., Yeh, C.-L., Wang, M.-L., Yang, Y.-P., Chen, Y.-M., Tsai, F.-T., Lee, M.-S., Cheng, Y.-H., Tsai, S.-K., Liu, P.-C., Chou, S.-J.^CA and Chiou, S.-H.^CA (2023/08). Modifications of Lipid Pathways Restrict SARS-CoV-2 Propagation in Human Induced Pluripotent Stem Cell-derived 3D Airway Organoids. Journal of Advanced Research. S2090-1232(23)00209-6. [SCI]

11.

Huang, H.-L., Huang, Y.-J., Chu, Y.-C., Chen, C.-W., Yang, H.-C., Hwang, J.-S., Chen, C.-h. and Chan, T.-C.^CA (2023/01). Exploring factors underlying poorly-controlled asthma in adults by integrating phenotypes and genotypes associated with obesity and asthma: A case-control study. Journal of Asthma and Allergy 16, 135-147. [SCI]

12.

Timoteo, V. J., Chiang, K.-M., Yang, H.-C. and Pan, W.-H. ^CA (2023/01). Common and ethnic-specific genetic determinants of hemoglobin concentration between Taiwanese Han Chinese and European whites: Findings from comparative two-stage genome-wide association studies. The Journal of Nutritional Biochemistry 111, 109126. [SCI]

13.

Huang, Y.-J., Chu, Y.-C., Chen, C.-W., Yang, H.-C., Huang, H.-L., Hwang, J.-S., Chen, C.-h. and Chan, T.-C.^CA (2022/12). Relationship among genetic variants, obesity traits, and asthma in the Taiwan Biobank. BMJ Open Respiratory Research 9, e001355. [SCI]

14.

Liang, Y.-J.^EC, Chiang, K.-M.^EC, Xiu, L.-L., Chung, C.-M., Shiao, M.-S., Cheng, M.-L., Kuo, C.-C., Yang, H.-C.^CA and Pan, W.-H.^CA (2022/11). Pharmacometabolomic study of drug response to antihypertensive medications for hypertension marker identification in Han Chinese individuals in Taiwan. Computational and Structural Biotechnology Journal 20, 6458–6466. [SCI] (MOST 109-2314-B-001-007-MY3). (https://doi.org/10.1016/j.csbj.2022.11.030)

15.

Yang, H.-C.^CA, Wang, J.-H., Yang, C.-T., Lin, Y.-C., Chen, P.-W., Liao, H.-C., Chen, C.-h. and Liao, J. C.^CA (2022/09). Subtyping of major SARS-CoV-2 variants reveals different transmission dynamics based on 10 million genomes. PNAS Nexus 1, pgac181. [SCI] (https://doi.org/10.1093/pnasnexus/pgac181)

16.

Lin, Y.-C., Liang, Y.-J. and Yang, H.-C.^CA (2022/07). Evaluating statistical significance in a meta-analysis by using numerical integration. Computational and Structural Biotechnology Journal 20, 3615–3620. [SCI] (MOST 109-2314-B-001-007-MY3) (https://doi.org/10.1016/j.csbj.2022.06.055)

17.

Chiang, K.-M., Chen, J.-F., Yang, C.-A., Xiu, L., Yang, H.-C., Shyur, L.F. and Pan, W.-H.^CA (2022/05). Identification of serum oxylipins associated with the development of coronary artery disease: A nested case-control study. Metabolites 12, 495. [SCI]

18.

Guo, C.-Y.^CA, Wang R.-H. and Yang, H.-C. (2021/04). Family-based gene-environment interaction using sequence kernel association test (FGE-SKAT) for complex quantitative traits. Scientific Reports 11, 7431. [SCI]

19.

Yang, H.-C.^CA, Chen, C.-W., Lin, Y.-T. and Chu, S.-K. (2021/02). Genetic ancestry plays a central role in population pharmacogenomics. Communications Biology 4, 171. [SCI] (https://rdcu.be/ceOYF)

20.

Yang, H.-C.^CA, Chen, C.-h., Wang, J.-H., Liao, H.-C., Yang, C.-T., Chen, C.-W., Lin, Y.-C., Kao, C.-H., Lu, M.-Y. J., and Liao, J. C.^CA (2020/12). Analysis of genomic distributions of SARS-CoV-2 reveals a dominant strain type with strong allelic associations. Proceedings of the National Academy of Sciences of the United States of America 117, 30679-30686. [SCI] (https://doi.org/10.1073/pnas.2007840117)

21.

Chiang, K.-M., Chang, H.-C., Yang, H.-C., Chen, C.-H., Chen, H.-H., Lee, W.-J., and Pan, W.-H.^CA (2019/11). Genome-wide association study of morbid obesity in Han-Chinese. BMC Genetics 20, 97. [SCI]

22.

Biradar, M. I., Chiang, K. M., Yang, H.-C., Huang, Y. T. and Pan, W.-P.^CA (2019/11) The causal role of elevated uric acid and waist circumference on the risk of metabolic syndrome components. International Journal of Obesity 44, 865-874. [SCI]

23.

Chiang, K.-M., Tsay, Y.-C., Ng, T.-C. V., Yang, H.-C., Huang, Y.-T., Chen, C.-H.^CA and Pan, W.-H.^CA (2019/08). Is hyperuricemia, an early-onset metabolic disorder, causally associated with cardiovascular disease events in Han Chinese? Journal of Clinical Medicine 8, 1202. [SCI]

24.

Apaya, M. K., Shiau, J.-Y., Liao, G.-S., Liang, Y.-J., Chen, C.-W., Yang, H.-C., Chu, C.-H., Yu, J.-C.^CA and Shyur, L.-F.^CA (2019/05). Integrated omics-based pathway analyses uncover CYP epoxygenase-associated networks as theranostic targets for metastatic triple negative breast cancer. Journal of Experimental & Clinical Cancer Research 38, 187. [SCI]

25.

Chen, C.-W. and Yang, H.-C.^CA (2019/01). OPATs: Omnibus p-value association tests. Briefings in Bioinformatics 20, 1-14. [SCI] (https://doi.org/10.1093/bib/bbx068)

26.

Lynn, K.-S., Cheng, M.-L., Yang, H.-C., Liang, Y.-J., Kang, M.-J., Chen, F.-L., Shiao, M.-S. and Pan, W.-H.^CA (2019/01). Vegetable signature derived from human urinary metabolomic data in controlled feeding studies. Journal of Proteome Research 18, 159-168. [SCI]

27.

Yang, H.-C.^CA and Chen, C.-W. (2018/09). Homozygosity disequilibrium associated with treatment response and its methylation regulation. BMC Proceedings 12, 45. [PubMed] (https://rdcu.be/6Z4m)

28.

Wang, P.-S., Kuo, C.-H., Yang, H.-C., Liang, Y.-J., Huang, C.-J., Sheen, L.-Y.^CA and Pan, W.-H.^CA (2018/05). Postprandial metabolomics response to various cooking oils in humans. Journal of Agricultural and Food Chemistry 66, 4977-4984. [SCI]

29.

Chiang, K.-M., Yang, H.-C. and Pan, W.-H.^CA (2018/01). A two-stage whole-genome gene expression association study of young-onset hypertension in Han Chinese population of Taiwan. Scientific Reports 8, 1800. [SCI]

30.

Chu, S.-K. and Yang, H.-C.^CA (2017/09). Interethnic DNA methylation difference and its implications in pharmacoepigenetics. Epigenomics 9, 1437-1454. [SCI] (https://doi.org/10.2217/epi-2017-0046)

31.

Yang, H.-C., Chen, I.-C., Tsay, Y.-C., Li, Z.-R., Chen, C.-H., Hwu, H.-G. and Chen, C.-H.^CA (2017/04). Using an event-history with risk-free model to study the genetics of alcoholism. Scientific Reports 7, 1975. [SCI] (http://rdcu.be/r18K)

32.

Kuo, H.-W., Shih, C.-L., Tsung, J.-H., Liu, S.-W., Chu, S.-K., Yang, H.-C., Tsou, H.-H., Wang, Z.-H., Chen, Andrew, C. H. and Liu, Y.-L.^CA (2017/03). Pharmacogenomics study on cadherin 2 network with regard to HIV infection and methadone treatment outcome. PLoS ONE 12, e0174647. [SCI]

33.

Chang, H.-C., Chang, H.-Y., Yang, H.-C., Yeh, C.-J. and Pan, W.-H.^CA (2017/01). Morbid obesity in Taiwan: Prevalence, trends, associated social demographics, and lifestyle factors. PLoS ONE 12, e01697577. [SCI]

34.

Yang, H.-C.^CA and Lin, Y.-T. (2016/11). Homozygosity disequilibrium and its gene regulation. BMC Proceedings 10, 159-163. [PubMed] (http://rdcu.be/mHtp)

35

Chen, S.-J, Lia, D.-L., Shen, T.-W., Yang, H.-C., Chen, K.-C. and Chen, C.-H.^CA (2016/08). Genetic signatures of heroin addiction. Medicine 95, e4473. [SCI]

36

Liang, Y.-J., Lin, Y.-T., Chen, C.-W., Lin, C.-W., Chao, K.-M.^EC, Pan, W.-H.^EC and Yang, H.-C.^{CA, EC} (2016/06). SMART: Statistical Metabolomics Analysis – an R tool. Analytical Chemistry 88, 6334-6341. [SCI] (https://doi.org/10.1021/acs.analchem.6b00603)

37.

Huang, M.-C., Chuang, T.-P., Chen, C.-H., Wu, J.-Y., Chen, Y.-T., Li, L.-H.^CA and Yang, H.-C.^CA (2016/03). An integrated analysis tool for hybridization intensities and genotypes using new-generation population-optimized human arrays. BMC Genomics 17, 266. [SCI] (https://rdcu.be/6i0w)

38.

Yang, H.-C., Chu, S.-K., Kuo, H.-W., Wang, S.-C., Liu, S.-W., Ho, I.-K. and Liu, Y.-L.^CA (2016/03). Genome-wide pharmacogenomic study on methadone maintenance treatment identifies SNP rs17180299 and multiple haplotypes on CYP2B6, SPON1, and GSG1L associated with plasma concentrations of methadone R- and S-enantiomers in heroin-dependent patients. PLoS Genetics 12, e1005910 [SCI] (https://doi.org/10.1371/journal.pgen.1005910)

39.

Konig, I. R.^CA, Auerbach, J., Gola, D., Held, E., Holzinger, E. R., Legault, M-A, Sun, R. Tintle, N. and Yang, H.-C. (2016/02). Machine learning and data mining in complex genomic data – a review on the lessons learned in Genetic Analysis Workshop 19. BMC Genetics 17, S2. [SCI]

40.

Leu, H.-B., Chung, C.-M., Lin, S.-J., Chiang, K.-M., Yang, H.-C., Ho, H.-Y., Ting, C.-T., Lin, T.-H., Sheu, S.-H., Tsai, W.-C., Chen, J.-H., Yin, W.-H., Chiu, T.-Y., Chen, C.-I., Fann, C. S. J., Chen, Y.-T., Pan, W.-H. and Chen, J.-W.^CA (2015/02). Association of circadian genes with diurnal blood pressure changes and non-dipper essential hypertension: a genetic association with young-onset hypertension. Hypertension Research 38, 155-162. [SCI]

41.

Yang, H.-C.^CA and Li, H.-W. (2014/06). Analysis of homozygosity disequilibrium using whole-genome sequencing data. BMC Proceedings 8, S15. [PubMed]

42.

Leu, H.-B., Chung, C.-M., Lin, S.-J., Lu, T.-M., Yang, H.-C., Ho, H.-Y., Ting, C.-T., Lin, T.-H., Sheu, S.-H., Tsai, W.-C., Chen, J.-H., Yin, W.-H., Chiu, T.-Y., Chen, C.-I., Pan, W.-H.^CA and Chen, J.-W.^CA (2014/06). A novel SNP associated with nighttime pulse pressure in young-onset hypertension factor for cardiovascular events in a general cohort in Taiwan A novel SNP associated with nighttime pulse pressure in young-onset hypertension factor for cardiovascular events in a general cohort in Taiwan. PLoS ONE 9, e97919. [SCI]

43.

Chiang, K.-M., Yang, H.-C., Liang, Y.-J., Chen, J.-W., Hwang, S.-M., Ho, H.-Y., Ting, C.-T., Lin, T.-H., Sheu, S.-H., Tsai, W.-C., Chen, J.-H., Leu, H.-B., Yin, W.-H., Chiu, T.-Y., Chen, C.-I., Lin, S.-J., Thomas, N. G., Tomlinson, B., Cherny, S., Gui, H. S., Sham, P. C., Lam, T. H. and Pan, W.-H.^CA (2014/06). A three-stage genome-wide association study combining multilocus test and gene expression analysis for young-onset hypertension on Taiwan Han Chinese. American Journal of Hypertension 27, 819-827. [SCI]

44.

Yang, H.-C.^CA, Lin, C.-W., Chen, C.-W. and Chen, J. J. (2014/04). Applying genome-wide gene-based expression quantitative trait locus mapping to study population ancestry and pharmacogenetics. BMC Genomics 15, 319. [SCI]

45.

Lai, C.-H., Chu, N.-F., Chang, C.-W., Wang, S.-L., Yang, H.-C., Chu, C.-M.^CA, Chang, C.-T., Lin, M.-H., Chien, W.-C., Su, S.-L., Chou, Y.-C., Chen, K.-H., Wang, W.-M. and Liou, S.-H. (2013/12). Androgenic alopecia is associated with less dietary soy, higher blood vanadium and rs11603121 polymorphism in Taiwanese communities. PLoS ONE 8, e79789. [SCI]

46.

Yang, H.-C.^EC, Liu, C.-M.^EC, Liu, Y.-L., Chen, C.-W., Chang, C. C., Fann, C. S. J., Chiou, J.-J., Yang, Y.-C., Chen, C.-H., Faraone, S. V., Tsuang, M. T. and Hwu, H.-G.^CA (2013/03). DAO gene plays an important role on genetic association and interaction to schizophrenia in the Taiwan Han Chinese population. PLoS ONE 8, e60099. [SCI]

47.

Chung, C.-M., Wang, R.-Y., Fann, C.S.J., Chen, J.-W., Jong, Y.-S., Jou, Y.-S., Yang, H.-C., Kang, C.-S., Chen, C.-C., Chang, H.-C. and Pan, W.-H.^CA (2013/03). Fine-mapping angiotensin-converting enzyme gene: separate QTLs identified for hypertension and for ACE activity. PLoS ONE 8, e56119. [SCI]

48.

Yang, H.-C.^CA, Wang, P.-L., Lin, C.-W., Chen, C.-H. and Chen, C.-H. (2012/07). Integrative analysis of single nucleotide polymorphisms and gene expression efficiently distinguishes samples from closely related ethnic populations. BMC Genomics 13, 346. [SCI] 

49.

Yang, H.-C.^CA, Chang, L.-C., Liang, Y.-J., Lin, C.-H. and Wang, P.-L. (2012/04). A genome-wide homozygosity association study identifies runs of homozygosity associated with rheumatoid arthritis in the human Major Histocompatibility Complex. PLoS ONE 7, e34840. [SCI]

50.

Lee, S.-C., Yang, Y.-H., Chuang, S.-Y., Liu, S.-C., Yang, H.-C. and Pan, W.-H.^CA (2012/03). Risk of asthma associated with energy-dense but nutrient-poor dietary pattern in Taiwanese children. Asia Pacific Journal of Clinical Nutrition 21, 73-81. [SCI]

51.

Yang, H.-C., Liang, Y.-J, Chen, J.-W., Chiang, K.-M., Chung, C.-M., Ho, H.-Y., Ting, C.-T., Lin, T.-H., Sheu, S.-H., Tsai, W.-C., Chen, J.-H., Leu, H.-B., Yin, W.-H., Chiu, T.-Y., Chern, C.-I., Lin, S.-J., Tomlinson, B., Guo, Y., Sham, P. C., Cherny S. S., Lam, T. H., Thomas, G. N. and Pan, W.-H.^CA (2012/03). Identification of IGF1, SLC4A4, WWOX, and SFMBT1 as Hypertension Susceptibility Genes in Han Chinese with a Genome-wide Gene-based Association Study. PLoS ONE 7, e32907. [SCI]

52.

Yang, H.-C.^CA and Chen, C.-W. (2011/11). Region-based and pathway-based QTL mapping using a p-value combination method. BMC Proceedings 5, S43. [PubMed]

53.

Chung C.-M., Lin, T.-H., Chen, J.-W., Leu, H.-B., Yang, H.-C., Ho, H.-Y., Ting, C.-T., Sheu, S.-H., Tsai, W.-C., Chen, J.-H., Lin, S.-J., Chen, Y.-T. and Pan, W.-H.^CA (2011/09). A genome-wide association study reveals a quantitative trait locus of adiponectin on CDH13 that predicts cardiometabolic outcomes. Diabetes 60, 2417-2423. [SCI]

54.

Yang, H.-C.^CA, Chang, L.-C., Huggins, R. M., Chen, C.-H. and Mullighan, C. G. (2011/05). LOHAS: Loss-of-heterozygosity analysis suite. Genetic Epidemiology 35, 247-260. [SCI]

55.

Yang, H.-C.^CA, Lin, H.-C., Kang, M., Chen, C.-H., Lin, C.-W., Li, L.-H., Wu, J.-Y., Chen, Y.-T. and Pan, W.-H. (2011/04). SAQC: SNP array quality control. BMC Bioinformatics 12, 100. [SCI]

56.

Yang, H.-C.^CA, Lin, H.-C., Huang, M.-C., Li, L.-H., Pan, W.-H., Wu, J.-Y. and Chen, Y.-T. (2010/07). A new analysis tool for individual-level allele frequency for genomic studies. BMC Genomics 11, 415. [SCI]

57.

Chiu, Y.-F.^CA, Kao, H.-Y., Chen, Y.-S., Hsu, F.-C. and Yang, H.-C. (2009/12). Assessment of gene-covariate interactions by incorporating covariates into association mapping. BMC Proceedings 3, S85. [PubMed]

58.

Yang, H.-C.^CA, Liang, Y.-J., Chung, C.-M., Chen, J.-W. and Pan, W.-H. (2009/12). Genome-wide gene-based association study. BMC Proceedings 3, S135. [PubMed]

59.

Yang, H.-C., Liang, Y.-J., Wu, Y.-L., Chung, C.-M., Chiang, K.-M., Ho, H.-Y., Ting, C.-T., Lin, T.-H., Sheu, S.-H., Tsai, W.-C., Chen, J.-H., Leu, H.-B., Yin, W.-H., Chiu, T.-Y., Chen, C.-I., Fann, C.S.J., Wu, J.-Y., Lin, T.-N., Lin, S.-J, Chen, Y.-T., Chen, J.-W.^CA and Pan, W.-H.^CA (2009/05). Genome-wide association study of young-onset hypertension in the Han Chinese Population of Taiwan. PLoS ONE 4, e5459. [SCI]

60.

Huggins, R., Li, L.-H., Lin, Y.-C., Yu, A.L.T. and Yang, H.-C.^CA (2008/12). Nonparametric estimation of LOH using Affymetrix SNP genotyping arrays for unpaired samples. Journal of Human Genetics 53, 983-990. [SCI]

61.

Zhang, H., Yang, H.-C. and Yang Y.^CA (2008/06). PoooL: An efficient method for estimating haplotypes from large DNA pools. Bioinformatics 24, 1942-1948. [SCI]

62

Yang, H.-C.^CA, Hsieh, H.-Y. and Fann, C. S. J. (2008/06). KBAT: Kernel-based association test. Genetics 179, 1057-1068. [SCI]

63

Lian, I.-B., Lin, Y.-H., Lin, Y.-C., Yang, H.-C., Chang, C.-J. and Fann, C. S. J.^CA (2008/05). Using the longest significance run to estimate region-specific p-values in genetic association mapping studies. BMC Bioinformatics 9, 246. [SCI]

64

Yang, H.-C.^CA, Huang, M.-C., Li, L.-H., Lin, C.-H., Yu, L. T., Diccianni, M. B., Wu, J.-Y., Chen, Y.-T. and Fann, C. S. J.^CA (2008/04). MPDA: microarray-based pooled DNA analyzer. BMC Bioinformatics 9, 196. [SCI]

65

Wang, R.-Y., Chung, C.-M., Fann, C.S.J., Yang, H.-C., Chen, J.-W., Jong, Y.-S., Jou, Y.-S., Lo, H.-M., Ho, F.-M., Kang, C.-S., Chen, C.-C., Chang, H.-C., Shyue, S.-K. and Pan, W.-H.^CA (2007/09). Genome-wide scan for quantitative ACE activity in Taiwan young-onset hypertension study. Human Heredity 65, 85-90. [SCI]

66

Yang, H.-C., Lin, C.-Y. and Fann, C. S. J.^CA (2006/09). A sliding-window weighted linkage disequilibrium test. Genetic Epidemiology 30, 531-545. [SCI]

67

Yang, H.-C., Liang, Y.-J., Huang, M.-C., Li, L.-H., Lin, C.-H., Wu, J.-Y., Chen, Y.-T. and Fann, C. S. J.^CA (2006/08). A genome-wide study of preferential amplification/hybridization in microarray-based pooled DNA experiments. Nucleic Acids Research 34, e106. [SCI]

68

Yang, H.-C., Lin, C.-H., Hsu, C.-L., Hung, S.-I., Wu, J.-Y., Pan, W.-H., Chen, Y.-T. and Fann, C. S. J.^CA (2006/07). A comparison of major histocompatibility complex SNPs in Han Chinese residing in Taiwan and Caucasians. Journal of Biomedical Science 13, 489-498. [SCI]

69

Yang, H.-C., Lin, C.-H., Hung, S.-I. and Fann, C. S. J.^CA (2006/05). A comparison of individual genotyping and pooled DNA analysis for polymorphism validation prior to large-scale genetic studies. Annals of Human Genetics 70, 350-359. [SCI]

70.

Yang, H.-C., Pan, C.-C., Lin, C.-Y. and Fann, C. S. J.^CA (2006/04). PDA: Pooled DNA analyzer. BMC Bioinformatics 7, 233. [SCI]

71

Yang, H.-C.^CA and Chao, A. (2005/12). Modeling animals’ behavioral response by Markov chain models for capture-recapture experiments. Biometrics 61, 1010-1017. [SCI]

72

Yang, H.-C., Chang, C.-C., Lin, C.-Y., Chen, C.-L., Lin, C.-Y. and Fann, C. S. J.^CA (2005/12). A genome-wide scanning and fine mapping study of COGA data. BMC Genetics 6, S30. [SCI]

73

Lo, Y.-L., Yu, J.-C., Chen, S.-T., Yang, H.-C., Fann, C. S. J., Mau, Y.-C. and Shen, C.-Y.^CA (2005/06). Breast cancer risk associated with genotypic polymorphism of the mitosis-regulating gene, Aurora-A/STK15/BTAK. International Journal of Cancer 115, 276-283. [SCI]

74

Yang, H.-C., Chambers, L. and Huggins, R. M.^CA (2005/04). A seasonal decomposition of the estimated size of a penguin population at Phillip Island, Australia. Australian Journal of Zoology 53, 111-115. [SCI]

75

Yang, H.-C., Pan C.-C., Lu, R. C. Y. and Fann, C. S. J.^CA (2005/01). New adjustment factors and sample size calculation in a DNA-pooling experiment with preferential amplification. Genetics 169, 399-410. [SCI] (NSC 92-3112-B-001-014 and 93IBMS2PP-C)

76

Lin, Y. M. J., Yang, H.-C., Lai, T. J., Fann, C. S. J. and Sun, H. S.^CA (2003/10). Receptor mediated effect of serotonergic transmission in patients with bipolar affective disorder. Journal of Medical Genetics 40, 781-786. [SCI]

77

Yang, H.-C., Huggins, R. M.^CA and Clark, A. (2003/06). Estimation of the size of an open population using local estimating equations II: A semi-parametric approach. Biometrics 59, 365-374. [SCI]

78

Yang, H.-C. and Huggins, R. M.^CA (2003/06). The estimation of the size of an open population using local estimating equations. Statistica Sinica 13, 673-689. [SCI]

79

Huggins, R. M.^CA, Yang, H.-C., Chao, A. and Yip, P. S. F. (2003/05). Population size estimation using local sample coverage for open populations. Journal of Statistical Planning and Inference 113, 699-714. [SCI]

- Software and Database

1.

CARE-2 (Capture-Recapture Part 2)

Website: http://chao.stat.nthu.edu.tw/wordpress/software_download/

2.

CARE-4 (Capture-Recapture Part 4)

Website: http://chao.stat.nthu.edu.tw/wordpress/software_download/

3.

Database of CPA (Coefficient of Preferential Amplification/Hybridization)  

Website: http://www.ibms.sinica.edu.tw/~csjfann/first flow/database.htm

4.

PDA (Pooled DNA Analyzer)  

Website: http://www.csjfann.ibms.sinica.edu.tw/eag/programlist/PDA/pda_1.html

5.

KBAT (Kernel-Based Association Test)

Website: http://staff.stat.sinica.edu.tw/hsinchou/genetics/association/KBAT.htm

6.

MPDA (Microarray Pooled DNA Analyzer)

Website: http://staff.stat.sinica.edu.tw/hsinchou/genetics/pooledDNA/mpda.htm

7.

ALOHA (Allele-Frequency/Loss-of-Heterozygosity/Allelic-Imbalance)

Website: http://staff.stat.sinica.edu.tw/hsinchou/genetics/aloha/ALOHA.htm

8.

AF database and CPA database

Website: http://hcyang.stat.sinica.edu.tw/index.htm

9.

LOHAS (Loss-Of-Heterozygosity Analysis Suite)

Website: http://staff.stat.sinica.edu.tw/hsinchou/genetics/loh/LOHAS.htm

10.

SAQC (SNP Array Quality Control)

Website: http://staff.stat.sinica.edu.tw/hsinchou/genetics/quality/SAQC.htm

11.

BIASLESS (Biomarkers Identification And Samples Subdivision)

Website: http://staff.stat.sinica.edu.tw/hsinchou/genetics/prediction/BIASLESS.htm

12.

Program and databases of gene-based eQTL (expression Quantitative Trait Loci)

Website: http://staff.stat.sinica.edu.tw/hsinchou/genetics/eQTL/HapMapII.htm

13.

ALICE (AF/LOH/LCSH/AI/CNV/CNA Enterprise)

Website: http://hcyang.stat.sinica.edu.tw/software/ALICE.html  

14.

SMART (Statistical Metabolomics Analysis – An R Tool)

Website: http://staff.stat.sinica.edu.tw/hsinchou/metabolomics/SMART.htm

15.

OPATs (Omnibus P-value Association Test)

Website: http://staff.stat.sinica.edu.tw/hsinchou/genetics/association/OPATs.htm

16.

Tracking SARS-CoV-2 Variations

Website: https://sarscov2.sinica.edu.tw/

17.

Genetic Ancestry PhD (Genetic Ancestry Pharmacogenomic Database)

Website: http://hcyang.stat.sinica.edu.tw/databases/genetic_ancestry_phd/

18

Pbine (P-value combine)

Website: https://github.com/Yinchun-Lin/Pbine

19

Type 2 Diabetes (T2D) Risk Calculator

Website: https://hcyang.stat.sinica.edu.tw/software/T2D_web/header.php

On-line courses

l   Fundamental Statistical Genomics

Others

l   Others.pdf

l   Biobank