|
楊欣洲博士個人網
|
|
|
楊欣洲
Hsin-Chou
Yang
Institute of
Statistical Science, Academia Sinica
Taipei 11529, Taiwan, R.O.C.
Tel: +886-27875686
FAX: +886-2-27886833
E-mail: hsinchou@stat.sinica.edu.tw
|
|
|
|
Narrative CV
Dr. Hsin-Chou
Yang is a statistician, bioinformatician, and data scientist specializing
in big data analytics for biomedical and life sciences. Currently, he is a
Full Research Fellow and Director at the Institute of Statistical Science,
Academia Sinica. Dr. Yang’s work bridges methodological innovation and
practical biomedical applications. His contributions span multi-omics
integration and precision & smart health. His team’s findings on
COVID-19 viral subtypes, published in PNAS and PNAS Nexus, on
AI-driven diabetes risk models, published in Nature Communications, and
on a large Han Chinese ancestry cohort for precision medicine, published in
Nature, exemplify impactful research. Dr. Yang has received numerous
honors, including the Presidential Scholar of Academia Sinica, the Future
Technology Breakthrough Award, and the National Innovation Award. He is an
elected member of the International Statistical Institute and the Global
Young Academy. He has served as an Associate Editor for major journals,
provided paper review for more than 70 journals, and has chaired several
national and international conferences. He actively mentors young
scientists and contributes to scientific policy and review boards.
Research Interests (PDF1, PDF2, PDF3)
|
|
|
|
Data
sciences for the multi-omics and precision & smart health studies (Project website)
|
|
Education
|
|
|
|
1990 - 1994
|
B.S., Department of Statistics,
National Cheng Kung University
|
|
|
|
1994 - 1996
|
M.S., Graduate Institute of Statistics,
National Cheng Kung University
|
|
|
|
1996 - 2002
|
Ph.D., Institute of Statistics,
National Tsing Hua University
|
|
Professional Experience
|
|
|
|
2002.10 - 2004.06
|
Postdoctoral Fellow of National Science
Council @ Institute of Biomedical Sciences, Academia Sinica [In military
service]
|
|
|
|
2004.07 - 2006.06
|
Postdoctoral Fellow of Academia Sinica
@ Institute of Biomedical Sciences, Academia Sinica [In military service]
|
|
|
|
2006.07 - 2011.03
|
Assistant Research Fellow @ Institute
of Statistical Science, Academia Sinica
|
|
|
|
2011.03 - 2018.01
|
Associate Research Fellow @ Institute
of Statistical Science, Academia Sinica
|
|
|
|
2018.01 - Present
|
Research Fellow @ Institute of
Statistical Science, Academia Sinica
|
|
Publications (CA Correspondence
author; EC Equal contribution; JS Joint supervision)
(Google
Scholar)
|
|
|
-
Journal Papers
|
|
|
|
1.
|
Huggins, R. M.CA,
Yang, H.-C., Chao, A. and
Yip, P. S. F. (2003/05). Population size estimation using local sample
coverage for open populations. Journal of
Statistical Planning and Inference 113, 699-714. [SCI]
|
|
|
|
2.
|
Yang, H.-C.
and Huggins, R. M.CA (2003/06). The estimation of the size
of an open population using local estimating equations. Statistica Sinica 13, 673-689. [SCI]
|
|
|
|
3.
|
Yang, H.-C.,
Huggins, R. M.CA and Clark,
A. (2003/06). Estimation of the size of an open population using local
estimating equations II: A semi-parametric approach. Biometrics 59, 365-374. [SCI]
|
|
|
|
4.
|
Lin, Y. M. J., Yang,
H.-C., Lai, T. J., Fann, C. S. J. and Sun, H. S.CA
(2003/10). Receptor mediated effect of serotonergic transmission in
patients with bipolar affective disorder. Journal
of Medical Genetics 40, 781-786. [SCI]
|
|
|
|
5.
|
Yang, H.-C., Pan C.-C., Lu, R. C. Y. and Fann, C. S. J.CA (2005/01). New
adjustment factors and sample size calculation in a DNA-pooling experiment
with preferential amplification. Genetics 169,
399-410. [SCI]
|
|
|
|
6.
|
Yang, H.-C., Chambers, L. and Huggins, R. M.CA
(2005/04). A seasonal decomposition of the estimated size of a penguin
population at Phillip Island, Australia. Australian Journal of Zoology 53,
111-115. [SCI]
|
|
|
|
7.
|
Lo, Y.-L., Yu, J.-C., Chen, S.-T., Yang, H.-C., Fann, C. S.
J., Mau, Y.-C. and Shen, C.-Y.CA (2005/06).
Breast cancer risk associated with genotypic polymorphism of the
mitosis-regulating gene, Aurora-A/STK15/BTAK. International Journal of Cancer
115, 276-283. [SCI]
|
|
|
|
8.
|
Yang, H.-C., Chang, C.-C.,
Lin, C.-Y., Chen, C.-L., Lin, C.-Y. and Fann, C. S. J.CA (2005/12). A
genome-wide scanning and fine mapping study of COGA data. BMC Genetics 6,
S30. [SCI]
|
|
|
|
9.
|
Yang, H.-C.CA
and Chao, A. (2005/12). Modeling animals’ behavioral response by Markov
chain models for capture-recapture experiments. Biometrics 61,
1010-1017. [SCI]
|
|
|
|
10.
|
Yang, H.-C., Pan, C.-C., Lin, C.-Y. and Fann, C.
S. J.CA (2006/04). PDA: Pooled DNA analyzer. BMC
Bioinformatics 7,
233. [SCI]
|
|
|
|
11.
|
Yang, H.-C., Lin, C.-H., Hung, S.-I. and Fann, C. S. J.CA (2006/05). A
comparison of individual genotyping and pooled DNA analysis for
polymorphism validation prior to large-scale genetic studies. Annals of Human Genetics 70, 350-359. [SCI]
|
|
|
|
12.
|
Yang, H.-C., Lin, C.-H., Hsu,
C.-L., Hung, S.-I., Wu, J.-Y., Pan, W.-H., Chen, Y.-T. and Fann, C. S. J.CA (2006/07). A comparison of major histocompatibility
complex SNPs in Han Chinese residing in Taiwan and Caucasians. Journal of Biomedical Science 13, 489-498. [SCI]
|
|
|
|
13.
|
Yang, H.-C., Liang, Y.-J., Huang, M.-C., Li, L.-H., Lin, C.-H.,
Wu, J.-Y., Chen, Y.-T. and Fann, C. S. J.CA (2006/08). A genome-wide study of preferential amplification/hybridization in
microarray-based pooled DNA experiments. Nucleic Acids Research
34, e106. [SCI]
|
|
|
|
14.
|
Yang, H.-C., Lin, C.-Y. and
Fann, C. S. J.CA
(2006/09). A sliding-window weighted linkage disequilibrium test. Genetic
Epidemiology 30,
531-545. [SCI]
|
|
|
|
15.
|
Wang,
R.-Y., Chung,
C.-M., Fann,
C.S.J., Yang, H.-C.,
Chen, J.-W.,
Jong, Y.-S.,
Jou, Y.-S.,
Lo, H.-M.,
Ho, F.-M.,
Kang, C.-S.,
Chen, C.-C.,
Chang, H.-C., Shyue, S.-K. and
Pan, W.-H.CA
(2007/09). Genome-wide scan for quantitative ACE activity in Taiwan
young-onset hypertension study.
Human
Heredity 65, 85-90.
[SCI]
|
|
|
|
16.
|
Yang, H.-C.CA,
Huang, M.-C., Li, L.-H., Lin, C.-H., Yu, L. T., Diccianni, M. B., Wu,
J.-Y., Chen, Y.-T. and Fann, C. S. J.CA
(2008/04). MPDA: microarray-based pooled DNA analyzer. BMC
Bioinformatics
9, 196. [SCI]
|
|
|
|
17.
|
Lian, I.-B., Lin, Y.-H.,
Lin, Y.-C., Yang, H.-C., Chang, C.-J. and Fann, C. S. J.CA
(2008/05). Using the longest significance run to estimate region-specific
p-values in genetic association mapping studies. BMC
Bioinformatics
9, 246. [SCI]
|
|
|
|
18.
|
Yang, H.-C.CA,
Hsieh, H.-Y. and Fann, C. S. J. (2008/06). KBAT: Kernel-based association
test. Genetics
179, 1057-1068. [SCI]
|
|
|
|
19.
|
Zhang, H., Yang, H.-C.
and Yang Y.CA (2008/06). PoooL: An efficient method
for estimating haplotypes from large DNA pools. Bioinformatics 24, 1942-1948. [SCI]
|
|
|
|
20.
|
Huggins, R., Li,
L.-H., Lin, Y.-C., Yu, A.L.T. and Yang, H.-C.CA
(2008/12). Nonparametric estimation of LOH using Affymetrix SNP genotyping
arrays for unpaired samples. Journal of Human Genetics 53, 983-990. [SCI]
|
|
|
|
21.
|
Yang, H.-C., Liang, Y.-J., Wu, Y.-L., Chung,
C.-M., Chiang, K.-M., Ho, H.-Y., Ting, C.-T., Lin, T.-H., Sheu, S.-H., Tsai,
W.-C., Chen, J.-H., Leu, H.-B., Yin, W.-H., Chiu, T.-Y., Chen, C.-I., Fann,
C.S.J., Wu, J.-Y., Lin, T.-N., Lin, S.-J, Chen, Y.-T., Chen, J.-W.CA
and Pan, W.-H.CA (2009/05). Genome-wide association
study of young-onset hypertension in the Han Chinese population of Taiwan. PLoS ONE 4,
e5459. [SCI]
|
|
|
|
22.
|
Yang, H.-C.CA,
Liang, Y.-J., Chung, C.-M., Chen, J.-W. and Pan, W.-H. (2009/12).
Genome-wide gene-based association study. BMC Proceedings 3, S135. [PubMed]
|
|
|
|
23.
|
Chiu, Y.-F.CA, Kao, H.-Y., Chen, Y.-S.,
Hsu, F.-C. and Yang, H.-C. (2009/12). Assessment of gene-covariate
interactions by incorporating covariates into association mapping. BMC
Proceedings 3, S85. [PubMed]
|
|
|
|
24.
|
Yang, H.-C.CA, Lin, H.-C., Huang,
M.-C., Li, L.-H., Pan, W.-H., Wu, J.-Y. and Chen, Y.-T. (2010/07). A new
analysis tool for individual-level allele frequency for genomic studies. BMC Genomics 11, 415. [SCI]
|
|
|
|
25.
|
Yang, H.-C.CA, Lin, H.-C., Kang, M., Chen,
C.-H., Lin, C.-W., Li, L.-H., Wu, J.-Y., Chen, Y.-T. and Pan, W.-H.
(2011/04). SAQC: SNP array
quality control. BMC
Bioinformatics 12, 100. [SCI]
|
|
|
|
26.
|
Yang, H.-C.CA, Chang, L.-C., Huggins,
R. M., Chen, C.-H. and Mullighan, C. G. (2011/05). LOHAS:
Loss-of-heterozygosity analysis suite. Genetic
Epidemiology 35, 247-260. [SCI]
|
|
|
|
27.
|
Chung C.-M.,
Lin, T.-H., Chen, J.-W., Leu, H.-B., Yang, H.-C., Ho, H.-Y., Ting, C.-T.,
Sheu, S.-H., Tsai, W.-C., Chen, J.-H., Lin, S.-J., Chen, Y.-T. and Pan,
W.-H.CA (2011/09). A genome-wide association study
reveals a quantitative trait locus of adiponectin on CDH13 that predicts cardiometabolic outcomes. Diabetes
60, 2417-2423. [SCI]
|
|
|
|
28.
|
Yang, H.-C.CA and Chen, C.-W.
(2011/11). Region-based and pathway-based QTL mapping using a p-value
combination method. BMC Proceedings 5,
S43. [PubMed]
|
|
|
|
29.
|
Yang, H.-C., Liang, Y.-J, Chen,
J.-W., Chiang, K.-M., Chung, C.-M., Ho, H.-Y., Ting, C.-T., Lin, T.-H.,
Sheu, S.-H., Tsai, W.-C., Chen, J.-H., Leu, H.-B., Yin, W.-H., Chiu, T.-Y.,
Chern, C.-I., Lin, S.-J., Tomlinson, B., Guo, Y., Sham, P. C., Cherny S.
S., Lam, T. H., Thomas, G. N. and Pan, W.-H.CA (2012/03). Identification
of IGF1, SLC4A4, WWOX and SFMBT1 as hypertension
susceptibility genes in Han Chinese population with a genome-wide
gene-based association study. PLoS ONE 7,
e32907. [SCI]
|
|
|
|
30.
|
Lee, S.-C.,
Yang, Y.-H., Chuang, S.-Y., Liu, S.-C., Yang, H.-C. and Pan, W.-H.CA
(2012/03). Risk of asthma associated with energy-dense but nutrient-poor
dietary pattern in Taiwanese children. Asia Pacific Journal of Clinical Nutrition 21, 73-81. [SCI]
|
|
|
|
31.
|
Yang, H.-C.CA, Chang, L.-C., Liang,
Y.-J., Lin, C.-H. and Wang, P.-L. (2012/04). A genome-wide homozygosity
association study identifies runs of homozygosity associated with
rheumatoid arthritis in the human Major Histocompatibility Complex. PLoS ONE 7,
e34840. [SCI]
|
|
|
|
32.
|
Yang, H.-C.CA, Wang, P.-L., Lin, C.-W.,
Chen, C.-H. and Chen, C.-H. (2012/07). Integrative analysis of single nucleotide
polymorphisms and gene expression efficiently distinguishes samples from
closely related ethnic populations. BMC
Genomics 13, 346. [SCI]
|
|
|
|
33.
|
Chung,
C.-M., Wang, R.-Y., Fann, C.S.J., Chen, J.-W., Jong, Y.-S., Jou, Y.-S., Yang,
H.-C.,
Kang, C.-S., Chen, C.-C., Chang,
H.-C. and Pan, W.-H.CA (2013/03). Fine-mapping
angiotensin-converting enzyme gene: separate QTLs identified for
hypertension and for ACE activity. PLoS
ONE 8, e56119. [SCI]
|
|
|
|
34.
|
Yang, H.-C.EC, Liu, C.-M.EC, Liu,
Y.-L., Chen, C.-W., Chang, C. C., Fann, C. S. J., Chiou, J.-J., Yang,
Y.-C., Chen, C.-H., Faraone, S. V., Tsuang, M. T. and Hwu, H.-G.CA (2013/03). DAO gene plays an important role on
genetic association and interaction to schizophrenia in the Taiwan Han
Chinese population. PLoS ONE 8, e60099.
[SCI]
|
|
|
|
35
|
Lai, C.-H., Chu, N.-F., Chang, C.-W., Wang, S.-L., Yang, H.-C., Chu, C.-M.CA,
Chang, C.-T., Lin, M.-H., Chien, W.-C., Su, S.-L., Chou, Y.-C., Chen,
K.-H., Wang, W.-M. and Liou, S.-H. (2013/12). Androgenic alopecia is
associated with less dietary soy, higher blood vanadium and rs11603121
polymorphism in Taiwanese communities. PLoS ONE 8, e79789. [SCI]
|
|
|
|
36
|
Yang, H.-C.CA, Lin,
C.-W., Chen, C.-W. and Chen, J. J. (2014/04).
Applying genome-wide gene-based expression quantitative trait locus mapping
to study population ancestry and pharmacogenetics. BMC Genomics 15, 319. [SCI]
|
|
|
|
37.
|
Chiang, K.-M., Yang, H.-C., Chen, J.-W., Hwang, S.-M.,
Ho, H.-Y., Ting, C.-T., Lin, T.-H., Sheu, S.-H., Tsai, W.-C., Chen, J.-H.,
Leu, H.-B., Yin, W.-H., Chiu, T.-Y., Chen, C.-I., Lin, S.-J., Thomas, N.
G., Tomlinson, B., Cherny, S., Gui, H. S., Sham, P. C., Lam, T. H. and Pan,
W.-H.CA (2014/06). A three-stage
genome-wide association study combining multilocus test and gene expression
analysis for young-onset hypertension on Taiwan Han Chinese. American
Journal of Hypertension 27,
819-827. [SCI]
|
|
|
|
38.
|
Leu, H.-B., Chung, C.-M., Lin, S.-J., Lu, T.-M., Yang, H.-C.,
Ho, H.-Y., Ting, C.-T., Lin, T.-H., Sheu, S.-H., Tsai, W.-C., Chen, J.-H.,
Yin, W.-H., Chiu, T.-Y., Chen, C.-I., Pan, W.-H. and Chen, J.-W. (2014/06).
A novel SNP associated with nighttime pulse pressure in young-onset hypertension
factor for cardiovascular events in a general cohort in Taiwan. PLoS ONE
9, e97919. [SCI]
|
|
|
|
39.
|
Yang, H.-C.CA and Li, H.-W. (2014/06). Analysis
of homozygosity disequilibrium using whole-genome sequencing data. BMC Proceedings 8,
S15. [PubMed]
|
|
|
|
40.
|
Leu, H.-B., Chung, C.-M., Lin,
S.-J., Chiang, K.-M., Yang, H.-C., Ho, H.-Y., Ting, C.-T., Lin,
T.-H., Sheu, S.-H., Tsai, W.-C., Chen, J.-H., Yin, W.-H., Chiu, T.-Y.,
Chen, C.-I., Fann, C. S. J., Chen, Y.-T., Pan, W.-H. and Chen, J.-W.CA (2015/02). Association of circadian genes with
diurnal blood pressure changes and non-dipper essential hypertension: a
genetic association with young-onset hypertension. Hypertension
Research 38,
155-162. [SCI]
|
|
|
|
41.
|
Konig, I. R.CA, Auerbach, J., Gola, D., Held,
E., Holzinger, E. R., Legault, M-A, Sun, R. Tintle, N. and Yang, H.-C. (2016/02). Machine learning and data
mining in complex genomic data – a review on the lessons learned in Genetic
Analysis Workshop 19. BMC Genetics 17, S2. [SCI]
|
|
|
|
42.
|
Huang, M.-C., Chuang, T.-P., Chen,
C.-H., Wu, J.-Y., Chen, Y.-T., Li, L.-H.CA and Yang, H.-C.CA (2016/03). An integrated
analysis tool for hybridization intensities and genotypes using
new-generation population-optimized human arrays. BMC Genomics 17, 266. [SCI]
|
|
|
|
43.
|
Yang, H.-C., Chu, S.-K., Kuo, H.-W., Wang, S.-C., Liu, S.-W.,
Ho, I.-K. and Liu, Y.-L.CA (2016/03).
Genome-wide pharmacogenomic study on methadone maintenance treatment
identifies SNP rs17180299 and multiple haplotypes on CYP2B6, SPON1, and GSG1L associated with plasma
concentrations of methadone R-
and S-enantiomers in
heroin-dependent patients. PLoS Genetics 12, e1005910.
[SCI] (https://doi.org/10.1371/journal.pgen.1005910)
|
|
|
|
44.
|
Liang, Y.-J., Lin, Y.-T., Chen,
C.-W., Lin, C.-W., Chao, K.-M.EC,
Pan, W.-H.EC and Yang, H.-C.CA, EC (2016/06). SMART:
Statistical Metabolomics Analysis - An R Tool. Analytical Chemistry 88, 6334-6341. [SCI] (https://doi.org/10.1021/acs.analchem.6b00603)
|
|
|
|
45.
|
Chen, S.-J, Lia, D.-L., Shen, T.-W., Yang, H.-C., Chen, K.-C. and Chen,
C.-H.CA (2016/08). Genetic signatures of heroin addiction. Medicine 95, e4473.
[SCI]
|
|
|
|
46.
|
Yang, H.-C.CA and Lin, Y.-T. (2016/11).
Homozygosity disequilibrium and its gene regulation. BMC Proceedings 10,
27. [PubMed] (http://rdcu.be/mHtp)
|
|
|
|
47.
|
Chang, H.-C., Chang, H.-Y., Yang, H.-C.,
Yeh, C.-J. and Pan, W.-H.CA (2017/01).
Morbid obesity in Taiwan: Prevalence, trends, associated social
demographics, and lifestyle factors. PLoS ONE 12, e01697557. [SCI]
|
|
|
|
48.
|
Kuo, H.-W., Shih, C.-L., Tsung, J.-H., Liu, S.-W., Chu,
S.-K., Yang, H.-C.,
Tsou, H.-H., Wang, Z.-H., Chen, Andrew, C. H. and Liu, Y.-L.CA (2017/03).
Pharmacogenomics study on cadherin 2 network with regard to HIV infection
and methadone treatment outcome. PLoS ONE 12, e0174647. [SCI]
|
|
|
|
49.
|
Yang, H.-C., Chen, I.-C., Tsay, Y.-C., Li, Z.-R., Chen, C.-H.,
Hwu, H.-G. and Chen, C.-H.CA (2017/04). Using
an event-history with risk-free model to study the genetics of alcoholism. Scientific
Reports 7,
1975. [SCI] (http://rdcu.be/r18K)
|
|
|
|
50.
|
Chu, S.-K. and Yang, H.-C.CA (2017/11). Interethnic DNA
methylation difference and its implications in pharmacoepigenetics. Epigenomics 9, 1437-1454. [SCI] (https://doi.org/10.2217/epi-2017-0046)
|
|
|
|
51.
|
Chiang, K.-M., Yang, H.-C.
and Pan, W.-H.CA (2018/01). A two-stage whole-genome gene expression association
study of young-onset hypertension in Han Chinese population of Taiwan. Scientific
Reports 8, 1800. [SCI]
|
|
|
|
52.
|
Wang, P.-S., Kuo, C.-H., Yang, H.-C., Liang, Y.-J., Huang,
C.-J., Sheen, L.-Y.CA and
Pan, W.-H.CA (2018/05). Postprandial
metabolomics response to various cooking oils in humans. Journal of
Agricultural and Food Chemistry 66, 4977-4984. [SCI]
|
|
|
|
53.
|
Yang, H.-C.CA and Chen, C.-W. (2018/09).
Homozygosity disequilibrium associated with treatment response and its
methylation regulation. BMC Proceedings 12,
45. [PubMed] (https://rdcu.be/6Z4m)
|
|
|
|
54.
|
Lynn, K.-S.,
Cheng, M.-L., Yang, H.-C., Liang, Y.-J., Kang, M.-J.,
Chen, F.-L., Shiao, M.-S. and Pan, W.-H.CA (2018/12). Vegetable signature derived from human urinary metabolomic
data in controlled feeding studies. Journal of Proteome Research (DOI:
10.1021/acs.jproteome.8b00470). [SCI]
|
|
|
|
55.
|
Chen, C.-W. and Yang, H.-C.CA (2019/01). OPATs: Omnibus
p-value association tests. Briefings in Bioinformatics 20, 1-14. [SCI] (https://doi.org/10.1093/bib/bbx068)
|
|
|
|
56.
|
Apaya,
M. K., Shiau, J.-Y., Liao, G.-S., Liang, Y.-J., Chen, C.-W., Yang, H.-C., Chu, C.-H., Yu, J.-C.CA and Shyur, L.-F.CA (2019/05). Integrated omics-based
pathway analyses uncover CYP epoxygenase-associated networks as theranostic
targets for metastatic triple negative breast cancer. Journal of Experimental & Clinical
Cancer Research 38,
187. [SCI]
|
|
|
|
57.
|
Chiang,
K.-M., Tsay, Y.-C., Ng, T.-C. V., Yang, H.-C., Huang, Y.-T., Chen, C.-H.CA and Pan, W.-H.CA (2019/08). Is hyperuricemia, an early-onset
metabolic disorder, causally associated with cardiovascular disease events
in Han Chinese? Journal of Clinical Medicine (doi:10.3390/jcm8081202). [SCI]
|
|
|
|
58.
|
Biradar,
M. I., Chiang, K. M., Yang, H.-C., Huang, Y. T. and Pan, W.-P.CA (2019/11) The causal role of elevated
uric acid and waist circumference on the risk of metabolic syndrome
components. International
Journal of Obesity
44, 865-874. [SCI]
|
|
|
|
59.
|
Chiang,
K.-M., Chang, H.-C., Yang, H.-C., Chen, C.-H., Chen, H.-H., Lee, W.-J. and Pan, W.-H.CA (2019/11). Genome-wide association study of morbid
obesity in Han-Chinese. BMC Genetics 20, 97. [SCI]
|
|
|
|
60.
|
Yang, H.-C.CA, Chen, C.-h., Wang, J.-H.,
Liao, H.-C., Yang, C.-T., Chen, C.-W., Lin, Y.-C., Kao, C.-H., Lu, M.-Y. J.
and Liao, J. C.CA (2020/12). Analysis of genomic
distributions of SARS-CoV-2 reveals a dominant strain type with strong
allelic associations. Proceedings of the National Academy of Sciences of the
United States of America 117, 48. [SCI] (https://doi.org/10.1073/pnas.2007840117)
|
|
|
|
61.
|
Yang, H.-C.CA, Chen, C.-W., Lin, Y.-T. and
Chu, S.-K. (2021/02). Genetic ancestry plays a central role in population pharmacogenomics. Communications
Biology 4, 171. [SCI]
(https://rdcu.be/ceOYF)
|
|
|
|
62
|
Guo,
C.-Y.CA, Wang R.-H. and Yang, H.-C. (2021/04). Family-based
gene-environment interaction using sequence kernel association test
(FGE-SKAT) for complex quantitative traits. Scientific Reports 11, 7431.
|
|
|
|
63
|
Chiang, K.-M., Chen, J.-F., Yang,
C.-A., Xiu, L., Yang, H.-C., Shyur,
L.F. and Pan, W.-H.CA (2022/05). Identification
of serum oxylipins associated with the development of coronary artery
disease: A nested case-control study. Metabolites 12, 495. [SCI]
|
|
|
|
64
|
Lin,
Y.-C., Liang, Y.-J. and Yang, H.-C.CA (2022/07). Evaluating
statistical significance in a meta-analysis by using numerical integration.
Computational
and Structural Biotechnology Journal 20, 3615–3620.
[SCI] (https://doi.org/10.1016/j.csbj.2022.06.055)
|
|
|
|
65
|
Yang, H.-C.CA, Wang, J.-H., Yang, C.-T.,
Lin, Y.-C., Chen, P.-W., Liao, H.-C., Chen, C.-h. and Liao, J. C.CA (2022/09). Subtyping of major SARS-CoV-2
variants reveals different transmission dynamics based on 10 million
genomes. PNAS
Nexus 1, pgac181. (https://doi.org/10.1093/pnasnexus/pgac181)
|
|
|
|
66
|
Liang,
Y.-J.EC, Chiang, K.-M.EC, Xiu, L.-L., Chung, C.-M.,
Shiao, M.-S., Cheng, M.-L., Kuo, C.-C., Yang, H.-C.CA and Pan, W.-H.CA (2022/11). Pharmacometabolomic
study of drug response to antihypertensive medications for hypertension
marker identification in Han Chinese individuals in Taiwan. Computational
and Structural Biotechnology Journal 20, 6458–6466. [SCI] (https://doi.org/10.1016/j.csbj.2022.11.030).
|
|
|
|
67
|
Huang, Y.-J., Chu, Y.-C., Chen,
C.-W., Yang, H.-C., Huang,
H.-L., Hwang, J.-S., Chen, C.-h. and Chan, T.-C.CA (2022/12). Relationship
among genetic variants, obesity traits, and asthma in the Taiwan Biobank. BMJ Open
Respiratory Research 9, e001355. [SCI]
|
|
|
|
68
|
Timoteo,
V. J., Chiang, K.-M., Yang, H.-C. and
Wen-Harn PanCA (2023/01). Common and
ethnic-specific genetic determinants of hemoglobin concentration between
Taiwanese Han Chinese and European whites: Findings from comparative
two-stage genome-wide association studies. The Journal of Nutritional Biochemistry
111, 109126. [SCI]
|
|
|
|
69
|
Huang, H.-L., Huang, Y.-J., Chu,
Y.-C., Chen, C.-W., Yang, H.-C.,
Hwang, J.-S., Chen, C.-h. and Chan, T.-C.CA (2023/01). Exploring factors
underlying poorly-controlled asthma in adults by integrating phenotypes and
genotypes associated with obesity and asthma: A case-control study. Journal of Asthma and Allergy 16, 135-147. [SCI]
|
|
|
|
70.
|
Tsai, P.-H., Sun, J.-R., Chien, Y., Chan, M.
S., Khor, W., Yang, H.-C., Huang, C.-H., Hsiung, C.-N., Hwa, T.-Y.,
Lin, Y.-Y., Yeh, C.-L., Wang, M.-L., Yang, Y.-P., Chen, Y.-M., Tsai, F.-T.,
Lee, M.-S., Cheng, Y.-H., Tsai, S.-K., Liu, P.-C., Chou, S.-J.CA and Chiou, S.-H.CA (2023/08). Modifications of Lipid Pathways
Restrict SARS-CoV-2 Propagation in Human Induced Pluripotent Stem
Cell-derived 3D Airway Organoids. Journal of Advanced Research. S2090-1232(23)00209-6.
[SCI]
|
|
|
|
71
|
Wang,
Y.-W., Yang, H.-C., Chen, Y.-H. and Guo, C.-Y.CA (2024/01). Generalized estimating equations
boosting (GEEB) machine for correlated data. Journal of Big Data 11, 20. [SCI]
|
|
|
|
72
|
Yen, T.-J.CA, Yang, C.-T., Lee, Y.-J., Chen, C.-h. and Yang, H.-C. (2024/03). Fatty liver classification via
risk controlled neural networks trained on grouped ultrasound image data. Scientific Reports 14, 7345. [SCI]
|
|
|
|
73
|
Huang, Y.-J., Chen, C.-h. and Yang, H.-C.CA (2024/05). AI-enhanced integration of genetic
and medical imaging data for risk assessment of type 2 diabetes. Nature
Communications 15, 4230. [SCI] (https://rdcu.be/dIiU4)
|
|
|
|
74
|
Dunneram, Y.CA,
Lee, J.Y., Watling, C.Z., Fraser, G.E., Miles, F., Prabhakaran, D.,
Shridhar, K., Kondal, D., Mohan, V., Ali, M.K., Narayan, K.M.V., Tandon,
N., Tong, T.Y.N., Chiu, T.H.T., Lin, M.-N., Lin, C.-L., Yang, H.-C. (17th),
Liang, Y.-J., Greenwood, D.C., Du, H., Chen, Z., Yu, C., Kakkoura, M.G.,
Reeves, G.K., Papier, K., Floud, S., Sinha, R., Liao, L.M., Loftfield, E.,
Cade, J.E., Key, T.J.CA,
Perez-Cornago, A. (2024/08). Methods and participant characteristics in the Cancer Risk
in Vegetarians Consortium: a cross-sectional analysis across 11 prospective
studies. BMC Public Health 24,
2095. [SCI]
|
|
|
|
75
|
Wei, C.-Y.CA,EC,
Wen, M.-S.EC, Cheng, C.-K.EC,
Sheen, Y.-J.EC, Yao, T.-C.EC,
Lee, S.-L.EC, Wu, J.-Y., Tsai,
M.-F., Li, L.-H., Chen, C.-h., Fann, C.S.J., Yang, H.-C. (12th),
Huang, Y.-T., Chen, H.-H., Liu, Y.-M., Yeh, E.-C., Peng, Y.-C., Wang,
S.-J., Chen, S.-P., Tsai, M.-T., Huo, T.-I., Su, C.-W., Tarng, D.-C.,
Huang, C.-C., Fuh, J.-L., Lan, K.-H., Liu, Y.-T., Lu, C.-L., Lee, Y.-C.,
Huang, Y.-H., Li, C.-P., Wang, Y.-F., Hsieh, Y.-C., Chen, Y.-M., Hsiao,
T.-H., Lin, C.-H., Chen, Y.-J., Chen, I.-C., Mao, C.-L., Chang, S.-J.,
Chang, Y.-L., Liao, Y.-J., Lai, C.-H., Lee, W.-J., Tung, H., Yen, T.-T.,
Yen, H.-C., Chang, J.-H., Huang, C.-Y., Chan, L., Lin, Y.-W., Hsiao, B.-Y.,
Hu, C.-J., Lin, Y.-K., Lin, Y.-F., Chang, T.-C., Wu, D.-C., Kan, J.-Y.,
Hsu, C.-Y., Chen, S.-C., Li, C.-C., Huang, C.-F., Sheu, C.-C., Yang, L.-J.,
Chen, C.-H., Chen, K.-M., Chang, S.-M., Liou, M.-S., Wang, S.-P., Lin,
K.-T., Chuang, H.-P., Chen, Y.-J., Sin, J., Chen, Y.-T., Chang, C.-C., Kuo,
C.-F., Lin, J.-C., Kuo, H.-C., Chan, T.-M., Lee, C.-W., Lai, J.-H., Luo,
S.-F., Cheng, H.-T., Lin, L.-Y., Chang, L.-C., Tsai, C.-T., Kao, H.-L., Yu,
J.-J., Jeng, J.-S., Chiu, M.-C., Hong, T.-C., Yang, S.-F., Lu, H.-J., Su,
S.-C., Chu, P., Li, P.-F., Tsai, C.-L., Tsai, C.-K., Tang, S.-E., Lin,
C.-M., Wu, Y.-F., Huang, C.-Y., Ling, S.-Z., Chang, C.-C., Lin, T.-K.,
Hsiao, S.-M., Chang, C.-H., Chen, C.-D., Ma, G.-C., Chang, T.-Y., Hwang,
J.-J., Lu, C.-L., Kao, K.-J., Hung, C.-F., Chen, S.-S., Chen, P.-Y., Tsui,
K., Chen, Y.-T., Chen, C.-H.CA,JS,
Chien, C.-C.CA,JS, Chiang, H.-S.CA,JS,
Chiu, Y.-L.CA,JS, Chen, H.-C.CA,JS,
Kwok, P.-Y.CA,JS (2025/06). Clinical impact of pharmacogenetic risk variants in a
large Chinese cohort. Nature Communications 16, 6344. [SCI]
(https://rdcu.be/eLNCX)
|
|
|
|
76
|
Yang, H.-C.CA,EC, Pui-Yan KwokCA,EC, Li, L.-H.EC, Liu, Y.-M.EC, Jong, Y.-J.EC, Lee, K.-Y.EC, Wang, D.-W., Tsai, M.-F., Yang, J.-H., Chen,
C.-H., Yeh, E.-C., Wei, C.-Y., Fann, C. S. J., Huang, Y.-T., Chen, C.-W.,
Lee, Y.-J., Chu, S.-K., Ho, C.-H., Yang, C.-S., Lee, Y. L., Chen, H.-H.,
Hou, M.-C., Chiou, J.-F., Yang, S.-F., Wang, C.-H., Huang, C.-Y., Chiu,
K.-M., Chen, M., Chiang, F.-T., Lee, S.-L., Chen, S.-S., Yao, W.-J., Chien,
C.-C., Lin, S.-Y., Chang, F.-P., Ho, H.-L., Yeh, Y.-C., Tseng, W.-C., Lin,
M.-H., Chang, H.-T., Tseng, L.-M., Liang, W.-Y., Chen, P. C.-H., Hang,
J.-F., Lin, S.-C., Chan, Y.-J., Kuo, Y.-J., Wang, L.-C., Pan, C.-C., Hsieh,
Y.-C., Chen, Y.-M., Hsiao, T.-H., Lin, C.-H., Chen, Y.-J., Chen, I.-C.,
Mao, C.-L., Chang, S.-J., Chang, Y.-L., Liao, Y.-J., Lai, C.-H., Lee,
W.-J., Tung, H., Yen, T.-T., Yen, H.-C., Shih, C.-M., Chou, T.-Y., Liou,
T.-H., Chiang, C.-Y., Cherng, Y.-G., Chen, C.-H., Chiu, C.-H., Tseng,
S.-H., Lin, E. P.-Y., Chen, Y.-J., Chuang, H.-P., Chen, T.-C., Huang,
W.-T., Sin, J., Liu, I.-L., Chen, Y.-C., Chao, K.-K., Wu, Y.-M., Yu, P.-P.,
Chang, L.-P., Yen, K.-Y., Chang, L.-C., Sheen, Y.-J., Chen, Y.-T., Kan, K.,
Tsai, H.-L., Wang, Y.-K., Hou, M.-F., Yang, Y.-H., Kuo, C.-H., Wu, W.-J.,
Huang, J.-F., Chong, I.-W., Tsai, J.-R., Lin, C.-Y., Yu, M.-C., Lee, T.-H.,
Tsai, M.-H., Ou, Y.-C., Chen, P.-Y., Hu, T.-H., Shyu, Y.-C., Cheng, C.-K.,
Fang, Y.-J., Hsieh, S.-C., Chen, C.-H., Chen, C.-C., Li, K.-J., Lin, C.-H.,
Chiu, H.-Y., Wu, C.-C., Chen, C.-Y., Chu, S.-J., Liu, F.-C., Yang, F.-C.,
Chang, H.-A., Chen, W.-L., Yang, S.-S., Sung, Y.-F., Wang, T.-F., Lin,
S.-Z., Wu, Y.-W., Wu, C.-S., Jiang, J.-Y., Ma, G.-C., Chang, T.-Y., Hwang,
J.-J., Kao, K.-J., Hung, C.-F., Chiu, T.-F., Chen, P.-Y., Tsui, K., Wu,
M.-S.JS, Pang, S.-T.JS, Chen, S.-A.JS, Chen, W.-M.JS, Chen, C.-h.JS, Sheu, Wayne H.-H.JS, Wu, J.-Y.CA,JS (2025/10). The Taiwan Precision Medicine
Initiative provides a cohort for large-scale studies. Nature. [SCI] (https://rdcu.be/eLNnv)
|
|
|
|
77
|
Chen, H.-H.CA,EC, Chen, C.-H.EC, Hou, M.-C.EC, Fu, Y.-C.EC, Li, L.-H., Chou, C.-Y., Yeh, E.-C., Tsai,
M.-F., Chen, C.-h., Yang, H.-C. (10th), Huang, Y.-T., Liu, Y.-M., Wei, C.-y.,
Su, J.-P., Lin, W.-J., Wang, E.H.F., Chiang, C.-L., Jiang, J.-K., Lee,
I.-H., Liang, K.-H., Chen, W.-S., Tsai, H.-C., Lin, S.-Y., Chang, F.-P.,
Ho, H.-L., Yeh, Y.-C., Tseng, W.-C., Lin, M.-H., Chang, H.-T., Tseng,
L.-M., Liang, W.-Y., Chen, P.C.-H., Hsieh, Y.-C., Chen, Y.-M., Hsiao,
T.-H., Lin, C.-H., Chen, Y.-J., Chen, I.-C., Mao, C.-L., Chang, S.-J.,
Chang, Y.-L., Liao, Y.-J., Lai, C.-H., Lee, W.-J., Tung, H., Yen, T.-T.,
Yen, H.-C., Chen, M.-Y., Lin, Y.-C., Kao, Y.-T., Kao, B.-Z., Lee, J.-E.,
Chung, C.-L., Liu, J.-C., Chan, P., Lin, C.-H., Chen, C.-H., Wu, I.-C.,
Lin, L.-C., Wang, J.-W., Shih, S.-L., Hsieh, S.-W., Hung, C.-H., Li, W.-M.,
Yang, C.-J., Yang, C.-S., Weng, R.-H., Chen, Y.-C., Chang, C.-P., Wu,
T.-H., Lin, Y.-C., Sheen, Y.-J., Wang, S.-H., Chen, S.-P., Raben, T.,
Widen, E., Hsu, S., Hsieh, F.-J., Ho, D.-R., Huang, Y.-H., Yang, C.-H.,
Huang, Y.-S., Chen, Y.-F., Wu, H.-M., Tsai, P.-H., Huang, K.-G., Chien,
C.-Y., Ho, Y.-L., Wu, M.-S., Kao, J.-H., Liu, Y.-B., Juang, J.-M.J., Lin,
M.-H., Lin, Y.-H., Lee, J.-Y., Lu, H.-J., Lu, C.-H., Feng, A.-C., Liu,
J.-S., Chiang, C.-P., Chu, N.-F., Lin, J.-C., Yeh, Y.-W., Meng, E., Huang,
C.-Y., Li, C.-C., Wang, T.-F., Su, K.-Y., Wang, J.-K., Chen, M.-H., Chen,
H.-F., Ma, G.-C., Chang, T.-Y., Chiang, F.-T., Chang, H.-J., Kao, K.-J.,
Hung, C.-F., Tsai, C.-Y., Chen, P.-Y., Tsui, K., Chen, Y.-T., Kwok, P.-Y.,
Sheu, W.H.-H.JS, Yang, S.-F.JS, Liou, J.-M.JS, Wang, J.-Y.JS, Chiou, J.-F.JS, Wu, J.-Y.JS, Fann, C. S. J.CA,JS
(2025/10). Population-Specific Polygenic Risk Scores Developed for the Han
Chinese. Nature. [SCI] (https://rdcu.be/eLMR9)
|
|
|
|
78
|
Liang, Y.-J., Yang, C.-T., Chen, C.-We., Lin,
Y.-C., Lin, S.-Y., Wang, Y.-S.CA and Yang, H.-C.CA (2025/10). SMART 2.0 Statistical Metabolomics
Analysis: An R Tool. Analytical Chemistry 97 (46), 25453–25468. [SCI] (https://doi.org/10.1021/acs.analchem.5c03225)
|
|
|
- Book Chapters
|
|
|
|
1.
|
Chao, A.CA, Yang, H.-C. and Yip,
P. S. F. (2003). The use of capture-recapture methodology in
epidemiological surveillance. pp. 711-739 in
Y. Lu and J.-Q. Fang (Ed.),
Advanced Medical Statistics. World Scientific Publishing Company, Singapore.
|
|
|
|
2.
|
Yang, H.-C. and Fann, C. S. J.CA (2007).
Association mapping using pooled DNA. pp. 161-175 in A. R. Collins (Ed.), Linkage Disequilibrium and Association Mapping, The Humana Press Inc., USA.
|
|
|
|
3.
|
Chao, A.CA,
Hsieh T. C. and Yang, H.-C. (2015). The use of
capture-recapture methodology in epidemiological surveillance and
ecological surveys. pp. 425-467 in Y. Lu, J.-Q. Fang, L. Tian and H. Jin
(Ed.), Advanced
Medical Statistics. 2nd Edition. World Scientific Publishing Company, Singapore.
|
|
|
|
|
|
|
|
|
|
- Scientific
Reports
|
|
|
|
1.
|
Geffers, J., Beaudry, C., Yang, H.-C., Huang,
F., Phanraksa, O., Dominik, M., Lin, Y.-C., Huang, M.-C., Komai, S.,
Lorimer, K., Piyawattanametha, W., Saengchantr, P., Saleh, H., Tagg, B. and
Veerakumarasivam, A. (2017/01). Global State of Young Scientists (GloSYS) in ASEAN –
Creativity and Innovation of Young Scientists in ASEAN. Editor: Global Young Academy. Halle, Germany (ISBN:
978-3-8047-3709-9).
|
|
|
|
2.
|
Yang, H.-C.CA,
Chen, C.-h., Wang, J.-H., Liao, H.-C., Yang, C.-T., Chen, C.-W., Lin,
Y.-C., Kao, C.-H. and Liao, J. C.CA (2020/04).
Genomic, geographic and temporal distributions of SARS-CoV-2 mutations. bioRxiv
(doi: https://doi.org/10.1101/2020.04.22.055863)
|
|
|
|
3
|
Yang, H.-C.CA,
Wang, J.-H., Yang, C.-T., Lin, Y.-C., Chen, P.-W., Liao, H.-C., Chen, C.-h.
and Liao, J. C.CA (2022/04). Subtyping of major
SARS-CoV-2 variants reveals different transmission dynamics. bioRxiv
(doi: https://doi.org/10.1101/2022.04.10.486823)
|
|
|
|
4
|
Huang, Y.-J., Chen, C.-h.
and Yang, H.-C.CA (2023/08).
AI-Enhanced Integration of Genetic and Medical Imaging Data for Risk
Assessment of Type 2 Diabetes. medRxiv (doi: https://doi.org/10.1101/2023.08.14.23294093)
|
|
|
|
5.
|
Huang, Y.-J., Chen, C.-h.
and Yang, H.-C.CA (2024/07). AI-driven Integration of Multimodal Imaging Pixel Data and
Genome-wide Genotype Data Enhances Precision Health for Type 2 Diabetes:
Insights from a Large-scale Biobank Study. medRxiv
(doi: https://doi.org/10.1101/2024.07.25.24310650)
|
|
