楊欣洲博士個人網

楊欣洲

Hsin-Chou Yang

Institute of Statistical Science, Academia Sinica
Taipei 11529, Taiwan, R.O.C.
Tel: +886-27875686
FAX: +886-2-27886833
E-mail: hsinchou@stat.sinica.edu.tw

Recent Research Achievements (中文, English)

Research Interests (PDF1, PDF2, PDF3)

Data sciences for the multi-omics and precision & smart health studies

Education

1990 - 1994

B.S., Department of Statistics, National Cheng Kung University

1994 - 1996

M.S., Graduate Institute of Statistics, National Cheng Kung University

1996 - 2002

Ph.D., Institute of Statistics, National Tsing Hua University

Professional Experience 

2002.10 - 2004.06

Postdoctoral Fellow of National Science Council @ Institute of Biomedical Sciences, Academia Sinica [In military service]

2004.07 - 2006.06

Postdoctoral Fellow of Academia Sinica @ Institute of Biomedical Sciences, Academia Sinica [In military service]

2006.07 - 2011.03

Assistant Research Fellow @ Institute of Statistical Science, Academia Sinica

2011.03 - 2018.01

Associate Research Fellow @ Institute of Statistical Science, Academia Sinica

2018.01 - Present

Research Fellow @ Institute of Statistical Science, Academia Sinica

Publications (^CA Correspondence author; ^EC Equal contribution) (Google Scholar)

- Journal Papers

1.

Huggins, R. M.^CA, Yang, H.-C., Chao, A. and Yip, P. S. F. (2003/05). Population size estimation using local sample coverage for open populations. Journal of Statistical Planning and Inference 113, 699-714. [SCI]

2.

Yang, H.-C. and Huggins, R. M.^CA (2003/06). The estimation of the size of an open population using local estimating equations. Statistica Sinica 13, 673-689. [SCI]

3.

Yang, H.-C., Huggins, R. M.^CA and Clark, A. (2003/06). Estimation of the size of an open population using local estimating equations II: A semi-parametric approach. Biometrics 59, 365-374. [SCI]

4.

Lin, Y. M. J., Yang, H.-C., Lai, T. J., Fann, C. S. J. and Sun, H. S.^CA (2003/10). Receptor mediated effect of serotonergic transmission in patients with bipolar affective disorder. Journal of Medical Genetics 40, 781-786. [SCI]

5.

Yang, H.-C., Pan C.-C., Lu, R. C. Y. and Fann, C. S. J.^CA (2005/01). New adjustment factors and sample size calculation in a DNA-pooling experiment with preferential amplification. Genetics 169, 399-410. [SCI]

6.

Yang, H.-C., Chambers, L. and Huggins, R. M.^CA (2005/04). A seasonal decomposition of the estimated size of a penguin population at Phillip Island, Australia. Australian Journal of Zoology 53, 111-115. [SCI]

7.

Lo, Y.-L., Yu, J.-C., Chen, S.-T., Yang, H.-C., Fann, C. S. J., Mau, Y.-C. and Shen, C.-Y.^CA (2005/06). Breast cancer risk associated with genotypic polymorphism of the mitosis-regulating gene, Aurora-A/STK15/BTAK. International Journal of Cancer 115, 276-283. [SCI]

8.

Yang, H.-C., Chang, C.-C., Lin, C.-Y., Chen, C.-L., Lin, C.-Y. and Fann, C. S. J.^CA (2005/12). A genome-wide scanning and fine mapping study of COGA data. BMC Genetics 6, S30. [SCI]

9.

Yang, H.-C.^CA and Chao, A. (2005/12). Modeling animals’ behavioral response by Markov chain models for capture-recapture experiments. Biometrics 61, 1010-1017. [SCI]

10.

Yang, H.-C., Pan, C.-C., Lin, C.-Y. and Fann, C. S. J.^CA (2006/04). PDA: Pooled DNA analyzer. BMC Bioinformatics 7, 233. [SCI]

11.

Yang, H.-C., Lin, C.-H., Hung, S.-I. and Fann, C. S. J.^CA (2006/05). A comparison of individual genotyping and pooled DNA analysis for polymorphism validation prior to large-scale genetic studies. Annals of Human Genetics 70, 350-359. [SCI]

12.

Yang, H.-C., Lin, C.-H., Hsu, C.-L., Hung, S.-I., Wu, J.-Y., Pan, W.-H., Chen, Y.-T. and Fann, C. S. J.^CA (2006/07). A comparison of major histocompatibility complex SNPs in Han Chinese residing in Taiwan and Caucasians. Journal of Biomedical Science 13, 489-498. [SCI]

13.

Yang, H.-C., Liang, Y.-J., Huang, M.-C., Li, L.-H., Lin, C.-H., Wu, J.-Y., Chen, Y.-T. and Fann, C. S. J.^CA (2006/08). A genome-wide study of preferential amplification/hybridization in microarray-based pooled DNA experiments. Nucleic Acids Research 34, e106. [SCI]

14.

Yang, H.-C., Lin, C.-Y. and Fann, C. S. J.^CA (2006/09). A sliding-window weighted linkage disequilibrium test. Genetic Epidemiology 30, 531-545. [SCI]

15.

Wang, R.-Y., Chung, C.-M., Fann, C.S.J., Yang, H.-C., Chen, J.-W., Jong, Y.-S., Jou, Y.-S., Lo, H.-M., Ho, F.-M., Kang, C.-S., Chen, C.-C., Chang, H.-C., Shyue, S.-K. and Pan, W.-H.^CA (2007/09). Genome-wide scan for quantitative ACE activity in Taiwan young-onset hypertension study. Human Heredity 65, 85-90. [SCI]

16.

Yang, H.-C.^CA, Huang, M.-C., Li, L.-H., Lin, C.-H., Yu, L. T., Diccianni, M. B., Wu, J.-Y., Chen, Y.-T. and Fann, C. S. J.^CA (2008/04). MPDA: microarray-based pooled DNA analyzer. BMC Bioinformatics 9, 196. [SCI]

17.

Lian, I.-B., Lin, Y.-H., Lin, Y.-C., Yang, H.-C., Chang, C.-J. and Fann, C. S. J.^CA (2008/05). Using the longest significance run to estimate region-specific p-values in genetic association mapping studies. BMC Bioinformatics 9, 246. [SCI]

18.

Yang, H.-C.^CA, Hsieh, H.-Y. and Fann, C. S. J. (2008/06). KBAT: Kernel-based association test. Genetics 179, 1057-1068. [SCI]

19.

Zhang, H., Yang, H.-C. and Yang Y.^CA (2008/06). PoooL: An efficient method for estimating haplotypes from large DNA pools. Bioinformatics 24, 1942-1948. [SCI]

20.

Huggins, R., Li, L.-H., Lin, Y.-C., Yu, A.L.T. and Yang, H.-C.^CA (2008/12). Nonparametric estimation of LOH using Affymetrix SNP genotyping arrays for unpaired samples. Journal of Human Genetics 53, 983-990. [SCI]

21.

Yang, H.-C., Liang, Y.-J., Wu, Y.-L., Chung, C.-M., Chiang, K.-M., Ho, H.-Y., Ting, C.-T., Lin, T.-H., Sheu, S.-H., Tsai, W.-C., Chen, J.-H., Leu, H.-B., Yin, W.-H., Chiu, T.-Y., Chen, C.-I., Fann, C.S.J., Wu, J.-Y., Lin, T.-N., Lin, S.-J, Chen, Y.-T., Chen, J.-W.^CA and Pan, W.-H.^CA (2009/05). Genome-wide association study of young-onset hypertension in the Han Chinese population of Taiwan. PLoS ONE 4, e5459. [SCI]

22.

Yang, H.-C.^CA, Liang, Y.-J., Chung, C.-M., Chen, J.-W. and Pan, W.-H. (2009/12). Genome-wide gene-based association study. BMC Proceedings 3, S135. [PubMed]

23.

Chiu, Y.-F.^CA, Kao, H.-Y., Chen, Y.-S., Hsu, F.-C. and Yang, H.-C. (2009/12). Assessment of gene-covariate interactions by incorporating covariates into association mapping. BMC Proceedings 3, S85. [PubMed]

24.

Yang, H.-C.^CA, Lin, H.-C., Huang, M.-C., Li, L.-H., Pan, W.-H., Wu, J.-Y. and Chen, Y.-T. (2010/07). A new analysis tool for individual-level allele frequency for genomic studies. BMC Genomics 11, 415. [SCI]

25.

Yang, H.-C.^CA, Lin, H.-C., Kang, M., Chen, C.-H., Lin, C.-W., Li, L.-H., Wu, J.-Y., Chen, Y.-T. and Pan, W.-H. (2011/04). SAQC: SNP array quality control. BMC Bioinformatics 12, 100. [SCI]

26.

Yang, H.-C.^CA, Chang, L.-C., Huggins, R. M., Chen, C.-H. and Mullighan, C. G. (2011/05). LOHAS: Loss-of-heterozygosity analysis suite. Genetic Epidemiology 35, 247-260. [SCI]

27.

Chung C.-M., Lin, T.-H., Chen, J.-W., Leu, H.-B., Yang, H.-C., Ho, H.-Y., Ting, C.-T., Sheu, S.-H., Tsai, W.-C., Chen, J.-H., Lin, S.-J., Chen, Y.-T. and Pan, W.-H.^CA (2011/09). A genome-wide association study reveals a quantitative trait locus of adiponectin on CDH13 that predicts cardiometabolic outcomes. Diabetes 60, 2417-2423. [SCI]

28.

Yang, H.-C.^CA and Chen, C.-W. (2011/11). Region-based and pathway-based QTL mapping using a p-value combination method. BMC Proceedings 5, S43. [PubMed]

29.

Yang, H.-C., Liang, Y.-J, Chen, J.-W., Chiang, K.-M., Chung, C.-M., Ho, H.-Y., Ting, C.-T., Lin, T.-H., Sheu, S.-H., Tsai, W.-C., Chen, J.-H., Leu, H.-B., Yin, W.-H., Chiu, T.-Y., Chern, C.-I., Lin, S.-J., Tomlinson, B., Guo, Y., Sham, P. C., Cherny S. S., Lam, T. H., Thomas, G. N. and Pan, W.-H.^CA (2012/03). Identification of IGF1, SLC4A4, WWOX and SFMBT1 as hypertension susceptibility genes in Han Chinese population with a genome-wide gene-based association study. PLoS ONE 7, e32907. [SCI]

30.

Lee, S.-C., Yang, Y.-H., Chuang, S.-Y., Liu, S.-C., Yang, H.-C. and Pan, W.-H.^CA (2012/03). Risk of asthma associated with energy-dense but nutrient-poor dietary pattern in Taiwanese children. Asia Pacific Journal of Clinical Nutrition 21, 73-81. [SCI]

31.

Yang, H.-C.^CA, Chang, L.-C., Liang, Y.-J., Lin, C.-H. and Wang, P.-L. (2012/04). A genome-wide homozygosity association study identifies runs of homozygosity associated with rheumatoid arthritis in the human Major Histocompatibility Complex. PLoS ONE 7, e34840. [SCI]

32.

Yang, H.-C.^CA, Wang, P.-L., Lin, C.-W., Chen, C.-H. and Chen, C.-H. (2012/07). Integrative analysis of single nucleotide polymorphisms and gene expression efficiently distinguishes samples from closely related ethnic populations. BMC Genomics 13, 346. [SCI]

33.

Chung, C.-M., Wang, R.-Y., Fann, C.S.J., Chen, J.-W., Jong, Y.-S., Jou, Y.-S., Yang, H.-C., Kang, C.-S., Chen, C.-C.,  Chang, H.-C. and Pan, W.-H.^CA (2013/03). Fine-mapping angiotensin-converting enzyme gene: separate QTLs identified for hypertension and for ACE activity. PLoS ONE 8, e56119. [SCI]

34.

Yang, H.-C.^EC, Liu, C.-M.^EC, Liu, Y.-L., Chen, C.-W., Chang, C. C., Fann, C. S. J., Chiou, J.-J., Yang, Y.-C., Chen, C.-H., Faraone, S. V., Tsuang, M. T. and Hwu, H.-G.^CA (2013/03). DAO gene plays an important role on genetic association and interaction to schizophrenia in the Taiwan Han Chinese population. PLoS ONE 8, e60099. [SCI]

35

Lai, C.-H., Chu, N.-F., Chang, C.-W., Wang, S.-L., Yang, H.-C., Chu, C.-M.^CA, Chang, C.-T., Lin, M.-H., Chien, W.-C., Su, S.-L., Chou, Y.-C., Chen, K.-H., Wang, W.-M. and Liou, S.-H. (2013/12). Androgenic alopecia is associated with less dietary soy, higher blood vanadium and rs11603121 polymorphism in Taiwanese communities. PLoS ONE 8, e79789. [SCI]

36

Yang, H.-C.^CA, Lin, C.-W., Chen, C.-W. and Chen, J. J. (2014/04). Applying genome-wide gene-based expression quantitative trait locus mapping to study population ancestry and pharmacogenetics. BMC Genomics 15, 319. [SCI]

37.

Chiang, K.-M., Yang, H.-C., Chen, J.-W., Hwang, S.-M., Ho, H.-Y., Ting, C.-T., Lin, T.-H., Sheu, S.-H., Tsai, W.-C., Chen, J.-H., Leu, H.-B., Yin, W.-H., Chiu, T.-Y., Chen, C.-I., Lin, S.-J., Thomas, N. G., Tomlinson, B., Cherny, S., Gui, H. S., Sham, P. C., Lam, T. H. and Pan, W.-H.^CA (2014/06). A three-stage genome-wide association study combining multilocus test and gene expression analysis for young-onset hypertension on Taiwan Han Chinese. American Journal of Hypertension 27, 819-827. [SCI]

38.

Leu, H.-B., Chung, C.-M., Lin, S.-J., Lu, T.-M., Yang, H.-C., Ho, H.-Y., Ting, C.-T., Lin, T.-H., Sheu, S.-H., Tsai, W.-C., Chen, J.-H., Yin, W.-H., Chiu, T.-Y., Chen, C.-I., Pan, W.-H. and Chen, J.-W. (2014/06). A novel SNP associated with nighttime pulse pressure in young-onset hypertension factor for cardiovascular events in a general cohort in Taiwan. PLoS ONE 9, e97919. [SCI]

39.

Yang, H.-C.^CA and Li, H.-W. (2014/06). Analysis of homozygosity disequilibrium using whole-genome sequencing data. BMC Proceedings 8, S15. [PubMed]

40.

Leu, H.-B., Chung, C.-M., Lin, S.-J., Chiang, K.-M., Yang, H.-C., Ho, H.-Y., Ting, C.-T., Lin, T.-H., Sheu, S.-H., Tsai, W.-C., Chen, J.-H., Yin, W.-H., Chiu, T.-Y., Chen, C.-I., Fann, C. S. J., Chen, Y.-T., Pan, W.-H. and Chen, J.-W.^CA (2015/02). Association of circadian genes with diurnal blood pressure changes and non-dipper essential hypertension: a genetic association with young-onset hypertension. Hypertension Research 38, 155-162. [SCI]

41.

Konig, I. R.^CA, Auerbach, J., Gola, D., Held, E., Holzinger, E. R., Legault, M-A, Sun, R. Tintle, N. and Yang, H.-C. (2016/02). Machine learning and data mining in complex genomic data – a review on the lessons learned in Genetic Analysis Workshop 19. BMC Genetics 17, S2. [SCI]

42.

Huang, M.-C., Chuang, T.-P., Chen, C.-H., Wu, J.-Y., Chen, Y.-T., Li, L.-H.^CA and Yang, H.-C.^CA (2016/03). An integrated analysis tool for hybridization intensities and genotypes using new-generation population-optimized human arrays. BMC Genomics 17, 266. [SCI]

43.

Yang, H.-C., Chu, S.-K., Kuo, H.-W., Wang, S.-C., Liu, S.-W., Ho, I.-K. and Liu, Y.-L.^CA (2016/03). Genome-wide pharmacogenomic study on methadone maintenance treatment identifies SNP rs17180299 and multiple haplotypes on CYP2B6, SPON1, and GSG1L associated with plasma concentrations of methadone R- and S-enantiomers in heroin-dependent patients. PLoS Genetics 12, e1005910. [SCI] (https://doi.org/10.1371/journal.pgen.1005910)

44.

Liang, Y.-J., Lin, Y.-T., Chen, C.-W., Lin, C.-W., Chao, K.-M.^EC, Pan, W.-H.^EC and Yang, H.-C.^{CA, EC} (2016/06). SMART: Statistical Metabolomics Analysis - An R Tool. Analytical Chemistry 88, 6334-6341. [SCI] (https://doi.org/10.1021/acs.analchem.6b00603)

45.

Chen, S.-J, Lia, D.-L., Shen, T.-W., Yang, H.-C., Chen, K.-C. and Chen, C.-H.^CA (2016/08). Genetic signatures of heroin addiction. Medicine 95, e4473. [SCI]

46.

Yang, H.-C.^CA and Lin, Y.-T. (2016/11). Homozygosity disequilibrium and its gene regulation. BMC Proceedings 10, 27. [PubMed] (http://rdcu.be/mHtp)

47.

Chang, H.-C., Chang, H.-Y., Yang, H.-C., Yeh, C.-J. and Pan, W.-H.^CA (2017/01). Morbid obesity in Taiwan: Prevalence, trends, associated social demographics, and lifestyle factors. PLoS ONE 12, e01697557. [SCI]

48.

Kuo, H.-W., Shih, C.-L., Tsung, J.-H., Liu, S.-W., Chu, S.-K., Yang, H.-C., Tsou, H.-H., Wang, Z.-H., Chen, Andrew, C. H. and Liu, Y.-L.^CA (2017/03). Pharmacogenomics study on cadherin 2 network with regard to HIV infection and methadone treatment outcome. PLoS ONE 12, e0174647. [SCI]

49.

Yang, H.-C., Chen, I.-C., Tsay, Y.-C., Li, Z.-R., Chen, C.-H., Hwu, H.-G. and Chen, C.-H.^CA (2017/04). Using an event-history with risk-free model to study the genetics of alcoholism. Scientific Reports 7, 1975. [SCI] (http://rdcu.be/r18K)

50.

Chu, S.-K. and Yang, H.-C.^CA (2017/11). Interethnic DNA methylation difference and its implications in pharmacoepigenetics. Epigenomics 9, 1437-1454. [SCI] (https://doi.org/10.2217/epi-2017-0046)

51.

Chiang, K.-M., Yang, H.-C. and Pan, W.-H.^CA (2018/01). A two-stage whole-genome gene expression association study of young-onset hypertension in Han Chinese population of Taiwan. Scientific Reports 8, 1800. [SCI]

52.

Wang, P.-S., Kuo, C.-H., Yang, H.-C., Liang, Y.-J., Huang, C.-J., Sheen, L.-Y.^CA and Pan, W.-H.^CA (2018/05). Postprandial metabolomics response to various cooking oils in humans. Journal of Agricultural and Food Chemistry 66, 4977-4984. [SCI]

53.

Yang, H.-C.^CA and Chen, C.-W. (2018/09). Homozygosity disequilibrium associated with treatment response and its methylation regulation. BMC Proceedings 12, 45. [PubMed] (https://rdcu.be/6Z4m)

54.

Lynn, K.-S., Cheng, M.-L., Yang, H.-C., Liang, Y.-J., Kang, M.-J., Chen, F.-L., Shiao, M.-S. and Pan, W.-H.^CA (2018/12). Vegetable signature derived from human urinary metabolomic data in controlled feeding studies. Journal of Proteome Research (DOI: 10.1021/acs.jproteome.8b00470). [SCI]

55.

Chen, C.-W. and Yang, H.-C.^CA (2019/01). OPATs: Omnibus p-value association tests. Briefings in Bioinformatics 20, 1-14. [SCI] (https://doi.org/10.1093/bib/bbx068)

56.

Apaya, M. K., Shiau, J.-Y., Liao, G.-S., Liang, Y.-J., Chen, C.-W., Yang, H.-C., Chu, C.-H., Yu, J.-C.^CA and Shyur, L.-F.^CA (2019/05). Integrated omics-based pathway analyses uncover CYP epoxygenase-associated networks as theranostic targets for metastatic triple negative breast cancer. Journal of Experimental & Clinical Cancer Research 38, 187. [SCI]

57.

Chiang, K.-M., Tsay, Y.-C., Ng, T.-C. V., Yang, H.-C., Huang, Y.-T., Chen, C.-H.^CA and Pan, W.-H.^CA (2019/08). Is hyperuricemia, an early-onset metabolic disorder, causally associated with cardiovascular disease events in Han Chinese? Journal of Clinical Medicine (doi:10.3390/jcm8081202). [SCI]

58.

Biradar, M. I., Chiang, K. M., Yang, H.-C., Huang, Y. T. and Pan, W.-P.^CA (2019/11) The causal role of elevated uric acid and waist circumference on the risk of metabolic syndrome components. International Journal of Obesity 44, 865-874. [SCI]

59.

Chiang, K.-M., Chang, H.-C., Yang, H.-C., Chen, C.-H., Chen, H.-H., Lee, W.-J. and Pan, W.-H.^CA (2019/11). Genome-wide association study of morbid obesity in Han-Chinese. BMC Genetics 20, 97. [SCI]

60.

Yang, H.-C.^CA, Chen, C.-h., Wang, J.-H., Liao, H.-C., Yang, C.-T., Chen, C.-W., Lin, Y.-C., Kao, C.-H., Lu, M.-Y. J. and Liao, J. C.^CA (2020/12). Analysis of genomic distributions of SARS-CoV-2 reveals a dominant strain type with strong allelic associations. Proceedings of the National Academy of Sciences of the United States of America 117, 48. [SCI] (https://doi.org/10.1073/pnas.2007840117)

61.

Yang, H.-C.^CA, Chen, C.-W., Lin, Y.-T. and Chu, S.-K. (2021/02). Genetic ancestry plays a central role in population pharmacogenomics. Communications Biology 4, 171. [SCI] (https://rdcu.be/ceOYF)

62

Guo, C.-Y.^CA, Wang R.-H. and Yang, H.-C. (2021/04). Family-based gene-environment interaction using sequence kernel association test (FGE-SKAT) for complex quantitative traits. Scientific Reports 11, 7431.

63

Chiang, K.-M., Chen, J.-F., Yang, C.-A., Xiu, L., Yang, H.-C., Shyur, L.F. and Pan, W.-H.^CA (2022/05). Identification of serum oxylipins associated with the development of coronary artery disease: A nested case-control study. Metabolites 12, 495. [SCI]

64

Lin, Y.-C., Liang, Y.-J. and Yang, H.-C.^CA (2022/07). Evaluating statistical significance in a meta-analysis by using numerical integration. Computational and Structural Biotechnology Journal 20, 3615–3620. [SCI] (https://doi.org/10.1016/j.csbj.2022.06.055)

65

Yang, H.-C.^CA, Wang, J.-H., Yang, C.-T., Lin, Y.-C., Chen, P.-W., Liao, H.-C., Chen, C.-h. and Liao, J. C.^CA (2022/09). Subtyping of major SARS-CoV-2 variants reveals different transmission dynamics based on 10 million genomes. PNAS Nexus 1, pgac181. (https://doi.org/10.1093/pnasnexus/pgac181)

66

Liang, Y.-J.^EC, Chiang, K.-M.^EC, Xiu, L.-L., Chung, C.-M., Shiao, M.-S., Cheng, M.-L., Kuo, C.-C., Yang, H.-C.^CA and Pan, W.-H.^CA (2022/11). Pharmacometabolomic study of drug response to antihypertensive medications for hypertension marker identification in Han Chinese individuals in Taiwan. Computational and Structural Biotechnology Journal 20, 6458–6466. [SCI] (https://doi.org/10.1016/j.csbj.2022.11.030).

67

Huang, Y.-J., Chu, Y.-C., Chen, C.-W., Yang, H.-C., Huang, H.-L., Hwang, J.-S., Chen, C.-h. and Chan, T.-C.^CA (2022/12). Relationship among genetic variants, obesity traits, and asthma in the Taiwan Biobank. BMJ Open Respiratory Research 9, e001355. [SCI]

68

Timoteo, V. J., Chiang, K.-M., Yang, H.-C. and Wen-Harn Pan^CA (2023/01). Common and ethnic-specific genetic determinants of hemoglobin concentration between Taiwanese Han Chinese and European whites: Findings from comparative two-stage genome-wide association studies. The Journal of Nutritional Biochemistry 111, 109126. [SCI]

69

Huang, H.-L., Huang, Y.-J., Chu, Y.-C., Chen, C.-W., Yang, H.-C., Hwang, J.-S., Chen, C.-h. and Chan, T.-C.^CA (2023/01). Exploring factors underlying poorly-controlled asthma in adults by integrating phenotypes and genotypes associated with obesity and asthma: A case-control study. Journal of Asthma and Allergy 16, 135-147. [SCI]

70.

Tsai, P.-H., Sun, J.-R., Chien Y., Chan, M. S., Khor, W., Yang, H.-C., Huang, C.-H., Hsiung, C.-N., Hwa, T.-Y., Lin, Y.-Y., Yeh, C.-L., Wang, M.-L., Yang, Y.-P., Chen, Y.-M., Tsai, F.-T., Lee, M.-S., Cheng, Y.-H., Tsai, S.-K., Liu, P.-C., Chou, S.-J.^CA and Chiou, S.-H.^CA (2023/08). Modifications of Lipid Pathways Restrict SARS-CoV-2 Propagation in Human Induced Pluripotent Stem Cell-derived 3D Airway Organoids. Journal of Advanced Research. S2090-1232(23)00209-6. [SCI]

71

Wang, Y.-W., Yang, H.-C., Chen, Y.-H. and Guo, C.-Y.^CA (2024/01). Generalized estimating equations boosting (GEEB) machine for correlated data. Journal of Big Data 11, 20. [SCI]

72

Yen, T.-J.^CA, Yang, C.-T., Lee, Y.-J., Chen, C.-h. and Yang, H.-C. (2024/03). Fatty liver classification via risk controlled neural networks trained on grouped ultrasound image data. Scientific Reports 14, 7345. [SCI]

73

Huang, Y.-J., Chen, C.-h. and Yang, H.-C.^CA (2024/05). AI-enhanced integration of genetic and medical imaging data for risk assessment of type 2 diabetes. Nature Communications 15, 4230. [SCI] (https://rdcu.be/dIiU4)

- Book Chapters

1.

Chao, A.^CA, Yang, H.-C. and Yip, P. S. F. (2003). The use of capture-recapture methodology in epidemiological surveillance. pp. 711-739 in Y. Lu and J.-Q. Fang (Ed.), Advanced Medical Statistics. World Scientific Publishing Company, Singapore.

2.

Yang, H.-C. and Fann, C. S. J.^CA (2007). Association mapping using pooled DNA. pp. 161-175 in A. R. Collins (Ed.), Linkage Disequilibrium and Association Mapping, The Humana Press Inc., USA.

3.

Chao, A.^CA, Hsieh T. C. and Yang, H.-C. (2015). The use of capture-recapture methodology in epidemiological surveillance and ecological surveys. pp. 425-467 in Y. Lu, J.-Q. Fang, L. Tian and H. Jin (Ed.), Advanced Medical Statistics. 2nd Edition. World Scientific Publishing Company, Singapore.

- Scientific Reports

1.

Geffers, J., Beaudry, C., Yang, H.-C., Huang, F., Phanraksa, O., Dominik, M., Lin, Y.-C., Huang, M.-C., Komai, S., Lorimer, K., Piyawattanametha, W., Saengchantr, P., Saleh, H., Tagg, B. and Veerakumarasivam, A. (2017/01). Global State of Young Scientists (GloSYS) in ASEAN – Creativity and Innovation of Young Scientists in ASEAN. Editor: Global Young Academy. Halle, Germany (ISBN: 978-3-8047-3709-9).

2.

Yang, H.-C.^CA, Chen, C.-h., Wang, J.-H., Liao, H.-C., Yang, C.-T., Chen, C.-W., Lin, Y.-C., Kao, C.-H. and Liao, J. C.^CA (2020/04). Genomic, geographic and temporal distributions of SARS-CoV-2 mutations. bioRxiv (doi: https://doi.org/10.1101/2020.04.22.055863)

3

Yang, H.-C.^CA, Wang, J.-H., Yang, C.-T., Lin, Y.-C., Chen, P.-W., Liao, H.-C., Chen, C.-h. and Liao, J. C.^CA (2022/04). Subtyping of major SARS-CoV-2 variants reveals different transmission dynamics. bioRxiv (doi: https://doi.org/10.1101/2022.04.10.486823)

4

Huang, Y.-J., Chen, C.-h. and Yang, H.-C.^CA (2023/08). AI-Enhanced Integration of Genetic and Medical Imaging Data for Risk Assessment of Type 2 Diabetes. medRxiv (doi: https://doi.org/10.1101/2023.08.14.23294093)

5.

Huang, Y.-J., Chen, C.-h. and Yang, H.-C.^CA (2024/07). AI-driven Integration of Multimodal Imaging Pixel Data and Genome-wide Genotype Data Enhances Precision Health for Type 2 Diabetes: Insights from a Large-scale Biobank Study. medRxiv (doi: https://doi.org/10.1101/2024.07.25.24310650)

- Software and Database

1.

CARE-2 (Capture-Recapture Part 2)

Website: http://chao.stat.nthu.edu.tw/wordpress/software_download/

2.

CARE-4 (Capture-Recapture Part 4)

Website: http://chao.stat.nthu.edu.tw/wordpress/software_download/

3.

Database of CPA (Coefficient of Preferential Amplification/Hybridization)  

Website: http://www.ibms.sinica.edu.tw/~csjfann/first flow/database.htm

4.

PDA (Pooled DNA Analyzer)  

Website: http://www.csjfann.ibms.sinica.edu.tw/eag/programlist/PDA/pda_1.html

5.

KBAT (Kernel-Based Association Test)

Website: http://staff.stat.sinica.edu.tw/hsinchou/genetics/association/KBAT.htm

6.

MPDA (Microarray Pooled DNA Analyzer)

Website: http://staff.stat.sinica.edu.tw/hsinchou/genetics/pooledDNA/mpda.htm

7.

ALOHA (Allele-Frequency/Loss-of-Heterozygosity/Allelic-Imbalance)

Website: http://staff.stat.sinica.edu.tw/hsinchou/genetics/aloha/ALOHA.htm

8.

AF database and CPA database

Website: http://hcyang.stat.sinica.edu.tw/index.htm

9.

LOHAS (Loss-Of-Heterozygosity Analysis Suite)

Website: http://staff.stat.sinica.edu.tw/hsinchou/genetics/loh/LOHAS.htm

10.

SAQC (SNP Array Quality Control)

Website: http://staff.stat.sinica.edu.tw/hsinchou/genetics/quality/SAQC.htm

11.

BIASLESS (Biomarkers Identification And Samples Subdivision)

Website: http://staff.stat.sinica.edu.tw/hsinchou/genetics/prediction/BIASLESS.htm

12.

Program and databases of gene-based eQTL (expression Quantitative Trait Loci)

Website: http://staff.stat.sinica.edu.tw/hsinchou/genetics/eQTL/HapMapII.htm

13.

ALICE (AF/LOH/LCSH/AI/CNV/CNA Enterprise)

Website: http://hcyang.stat.sinica.edu.tw/software/ALICE.html  

14.

SMART (Statistical Metabolomics Analysis – An R Tool)

Website: http://staff.stat.sinica.edu.tw/hsinchou/metabolomics/SMART.htm

15.

OPATs (Omnibus P-value Association Test)

Website: http://staff.stat.sinica.edu.tw/hsinchou/genetics/association/OPATs.htm

16.

Tracking SARS-CoV-2 Variations

Website: https://sarscov2.sinica.edu.tw/

17.

Genetic Ancestry PhD (Genetic Ancestry Pharmacogenomic Database)

Website: http://hcyang.stat.sinica.edu.tw/databases/genetic_ancestry_phd/

18

Pbine (P-value combine)

Website: https://github.com/Yinchun-Lin/Pbine

19

Type 2 Diabetes (T2D) Risk Calculator

Website: https://hcyang.stat.sinica.edu.tw/software/T2D_web/header.php

On-line courses

l   Fundamental Statistical Genomics

Others

l   Others.pdf

l   Biobank