Welcome to the MPDA website

Introduction:

Microarray-based pooled DNA experiments that combine the merits of DNA pooling and gene chip technology constitute a pivotal advance in biotechnology. This new technique uses pooled DNA, thereby reducing costs associated with the typing of DNA from numerous individuals. Moreover, use of an oligonucleotide gene chip reduces costs related to processing DNA (e.g., primers, reagents). Thus, the technique provides an overall cost-effective solution for large-scale genomic/genetic research. MPDA is an innovative tool for analyzing hybridization intensity data from microarray-based pooled DNA experiments. Graphic and numerical outputs from MPDA support global and detailed inspection for bulk of genomic data.

Functionality:

MPDA provides four major functions: (1) Whole-genome DNA amplification/hybridization analysis, (2) Allele frequency estimation, (3) Association mapping, (4) Allelic imbalance detection.

Download software MPDA:

CONTENT	NAME	SIZE	UPDATE
Execution with a graphical user-friendly interface	MPDA	82.3 MB	2008-11-10
MATLAB® Component Runtime Libraries	MCRInstaller	171 MB	2007-12-18
Execution on machines without installing MATLAB® (Programs, databases and 2 examples)	MPDA	71.7 MB	2008-04-02
Execution on machines without installing MATLAB® (Programs and databases)	MPDA	28.9 MB	2008-04-02

Download other examples:

　

Illustration of the following 8 examples - Execution with a graphic user-friendly interface 

　

Illustration of the following 8 examples - Execution on machines without installing MATLAB®

　

Example	1	2	3	4	5	6	7	8
Input
Output

Download user manual:

　

MPDA user manual

Reference:

　

Hsin-Chou Yang, Mei-Chu Huang, Ling-Hui Li, Chien-Hsing Lin, Alice L. T. Yu, Mitchell B. Diccianni, Jer-Yuan Wu, Yuarn-Tsong Chen, Cathy S. J. Fann (2008). MPDA: Microarray Pooled DNA Analyzer. BMC Bioinformatics. 9:196.

Contact:

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Please send an e-mail to hsinchou@stat.sinica.edu.tw if you have downloaded MPDA. We will inform you if an update of MPDA is available. Any questions/comments/suggestions on MPDA are highly appreciated. Your feedback definitely helps improve MPDA.